1-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxyphenyl}methanamine

Base Information

Chemical Name:1-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxyphenyl}methanamine
CAS No.:1438425-47-8
Molecular Formula:C₂₀H₂₁ClN₂O₃
Molecular Weight:372.851
Hs Code.:

Synonyms:1-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxyphenyl}methanamine

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Chemical Property of 1-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxyphenyl}methanamine

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Technology Process of 1-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxyphenyl}methanamine

There total 6 articles about 1-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxyphenyl}methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1438425-44-5
4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxybenzonitrile

: 1438425-47-8
1-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxyphenyl}methanamine

Guidance literature:: 4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxybenzonitrile; With lithium aluminium tetrahydride; In diethyl ether; at -78 - 0 ℃; for 2.5h; Inert atmosphere;

With sodium hydroxide; In water;
DOI:10.1016/j.bmcl.2013.04.035

Reference yield:

: 1438425-40-1
4-(2-chloro-4-formylphenoxy)-3-methoxybenzonitrile

: 1438425-47-8
1-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxyphenyl}methanamine

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium hydroxide / water; ethanol / 1.5 h / 20 °C / Cooling

2: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

3: sodium L-ascorbate; copper(ll) sulfate pentahydrate; potassium hydrogencarbonate / water; tert-butyl alcohol / 1 h / 20 °C

4: lithium aluminium tetrahydride / diethyl ether / 2.5 h / -78 - 0 °C / Inert atmosphere

With N-chloro-succinimide; lithium aluminium tetrahydride; copper(ll) sulfate pentahydrate; hydroxylamine hydrochloride; potassium hydrogencarbonate; sodium L-ascorbate; sodium hydroxide; In diethyl ether; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2013.04.035

Reference yield:

: 1438425-41-2
4-{2-chloro-4-[(E)-(hydroxyimino)methyl]phenoxy}-3-methoxybenzonitrile

: 1438425-47-8
1-{4-[2-chloro-4-(5-propyl-1,2-oxazol-3-yl)phenoxy]-3-methoxyphenyl}methanamine

Guidance literature:: Multi-step reaction with 3 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

2: sodium L-ascorbate; copper(ll) sulfate pentahydrate; potassium hydrogencarbonate / water; tert-butyl alcohol / 1 h / 20 °C

3: lithium aluminium tetrahydride / diethyl ether / 2.5 h / -78 - 0 °C / Inert atmosphere

With N-chloro-succinimide; lithium aluminium tetrahydride; copper(ll) sulfate pentahydrate; potassium hydrogencarbonate; sodium L-ascorbate; In diethyl ether; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2013.04.035