2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

Base Information

Chemical Name:2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid
CAS No.:1242850-02-7
Molecular Formula:C₁₇H₁₉ClN₂O₅S
Molecular Weight:398.867
Hs Code.:

Synonyms:2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

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Chemical Property of 2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

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Technology Process of 2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

There total 8 articles about 2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242850-24-3
tert-Butyl 2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate

: 1242850-02-7
2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

Guidance literature:: tert-Butyl 2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With potassium hydrogensulfate; In dichloromethane; water; Cooling with ice;

Reference yield:

: 73627-16-4
N-[2-(1H-pyrrol-1-yl)ethyl]acetamide

: 1242850-02-7
2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / water / 24 h / Reflux

2.1: triethylamine / dichloromethane / 0 - 5 °C / Inert atmosphere

3.1: trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

3.2: pH > 7

4.1: water; sodium tetrahydroborate / methanol / 1.17 h / 0 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

6.2: 24 h / 20 °C / Inert atmosphere

7.1: sodium hydroxide / tetrabutyl-ammonium chloride / dichloromethane; water / 3 h / 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

8.2: Cooling with ice

With sodium tetrahydroborate; lithium borohydride; water; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; tetrabutyl-ammonium chloride; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 29709-35-1
1-(2-aminoethyl)pyrrole

: 1242850-02-7
2-((2-(2-chloro-6-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0 - 5 °C / Inert atmosphere

2.1: trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

2.2: pH > 7

3.1: water; sodium tetrahydroborate / methanol / 1.17 h / 0 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

5.2: 24 h / 20 °C / Inert atmosphere

6.1: sodium hydroxide / tetrabutyl-ammonium chloride / dichloromethane; water / 3 h / 20 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

7.2: Cooling with ice

With sodium tetrahydroborate; lithium borohydride; water; triethylamine; trifluoroacetic acid; sodium hydroxide; tetrabutyl-ammonium chloride; In tetrahydrofuran; methanol; dichloromethane; water;