[2-(4-{3-[2-(4-Chloro-phenyl)-ethyl]-thioureidomethyl}-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:[2-(4-{3-[2-(4-Chloro-phenyl)-ethyl]-thioureidomethyl}-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:1026883-06-6
Molecular Formula:C₃₅H₃₆ClN₃O₄S
Molecular Weight:630.208
Hs Code.:

Synonyms:[2-(4-{3-[2-(4-Chloro-phenyl)-ethyl]-thioureidomethyl}-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of [2-(4-{3-[2-(4-Chloro-phenyl)-ethyl]-thioureidomethyl}-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of [2-(4-{3-[2-(4-Chloro-phenyl)-ethyl]-thioureidomethyl}-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 6 articles about [2-(4-{3-[2-(4-Chloro-phenyl)-ethyl]-thioureidomethyl}-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 17608-10-5
2-(4-chlorophenyl)ethyl isothiocyanate

: [2-(4-Aminomethyl-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester; compound with trifluoro-acetic acid

: 1026883-06-6
[2-(4-{3-[2-(4-Chloro-phenyl)-ethyl]-thioureidomethyl}-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1021/jm960512h

Reference yield:

: 7149-10-2
vanillylamine hydrochloride

: 1026883-06-6
[2-(4-{3-[2-(4-Chloro-phenyl)-ethyl]-thioureidomethyl}-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / Et₃N / H₂O; dioxane / Ambient temperature

2: 77 percent / 40percent aq. KOH, 40percent aq. tetrabutylammonium hydroxide / 3 h / 50 °C

3: 76 percent / ethanol / 6 h / Heating

4: 93 percent / Et₃N / dioxane; H₂O / 6 h / Ambient temperature

5: 100 percent / CH₂Cl₂ / Ambient temperature

6: 96 percent / 5 M NaOH / dimethylformamide

With potassium hydroxide; sodium hydroxide; tetra(n-butyl)ammonium hydroxide; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm960512h

Reference yield:

: 130972-89-3
(4-hydroxy-3-methoxybenzyl)carbamic acid tert-butyl ester

: 1026883-06-6
[2-(4-{3-[2-(4-Chloro-phenyl)-ethyl]-thioureidomethyl}-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / 40percent aq. KOH, 40percent aq. tetrabutylammonium hydroxide / 3 h / 50 °C

2: 76 percent / ethanol / 6 h / Heating

3: 93 percent / Et₃N / dioxane; H₂O / 6 h / Ambient temperature

4: 100 percent / CH₂Cl₂ / Ambient temperature

5: 96 percent / 5 M NaOH / dimethylformamide

With potassium hydroxide; sodium hydroxide; tetra(n-butyl)ammonium hydroxide; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm960512h