3-(5-bromo-4-isopropyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2-morpholinoethyl)-4-propoxybenzenesulfonamide

Base Information

Chemical Name:3-(5-bromo-4-isopropyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2-morpholinoethyl)-4-propoxybenzenesulfonamide
CAS No.:1229017-23-5
Molecular Formula:C₂₂H₃₁BrN₄O₅S
Molecular Weight:543.482
Hs Code.:

Synonyms:3-(5-bromo-4-isopropyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2-morpholinoethyl)-4-propoxybenzenesulfonamide

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Chemical Property of 3-(5-bromo-4-isopropyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2-morpholinoethyl)-4-propoxybenzenesulfonamide

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Technology Process of 3-(5-bromo-4-isopropyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2-morpholinoethyl)-4-propoxybenzenesulfonamide

There total 4 articles about 3-(5-bromo-4-isopropyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2-morpholinoethyl)-4-propoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1229020-08-9
C₁₆H₁₈BrClN₂O₄S

: 1229017-23-5
3-(5-bromo-4-isopropyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2-morpholinoethyl)-4-propoxybenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2013.06.062

Reference yield:

: 1229019-43-5
2-(2-n-propoxyphenyl)-6-isopropylpyrimid-4(3H)-one

: 1229017-23-5
3-(5-bromo-4-isopropyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2-morpholinoethyl)-4-propoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; pyridine / dichloromethane / 0.17 h / 0 °C

2: chlorosulfonic acid / 2 h / 0 °C

3: triethylamine / dichloromethane / 0.5 h / 0 °C

With pyridine; chlorosulfonic acid; bromine; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2013.06.062

Reference yield:

: 1229019-44-6
5-bromo-6-isopropyl-2-(2-propoxyphenyl)pyrimidin-4(3H)-one

: 1229017-23-5
3-(5-bromo-4-isopropyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2-morpholinoethyl)-4-propoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: chlorosulfonic acid / 2 h / 0 °C

2: triethylamine / dichloromethane / 0.5 h / 0 °C

With chlorosulfonic acid; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2013.06.062