S-(-)-SKF-38393 hydrochloride

Base Information

Chemical Name:S-(-)-SKF-38393 hydrochloride
CAS No.:62717-94-6
Molecular Formula:C₁₆H₁₇NO₂*ClH
Molecular Weight:291.777
Hs Code.:
UNII:9HG702RD4N
ChEMBL ID:CHEMBL2093929

Synonyms:S-(-)-SKF-38393 hydrochloride;9HG702RD4N;SKF-38393 hydrochloride, (S)-;62717-94-6;1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride (1:1), (1S)-;UNII-9HG702RD4N;SCHEMBL7201583;CHEMBL2093929;MFCD00069365;S(-)-SKF-38393 HYDROCHLORIDE;S-(-)-SKF-38393 hydrochloride, solid

Suppliers and Price of S-(-)-SKF-38393 hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of S-(-)-SKF-38393 hydrochloride

Chemical Property:

Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:291.1026065
Heavy Atom Count:20
Complexity:291

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl
Isomeric SMILES:C1CNC[C@H](C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl

Technology Process of S-(-)-SKF-38393 hydrochloride

There total 5 articles about S-(-)-SKF-38393 hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 42738-59-0
(1S)-(-)-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 62717-94-6,62717-42-4
(-)-SKF 38393 hydrochloride

Guidance literature:: With hydrogenchloride; Heating;
DOI:10.1021/jm00086a016

Reference yield:

: 62717-93-5
(S)-3-benzyl-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrochloride

: 62717-94-6,62717-42-4
(-)-SKF 38393 hydrochloride

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; at 25 ℃; for 2h; under 3102.9 Torr; Yield given;
DOI:10.1021/jm00348a017

Reference yield:

: 20569-49-7
7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 62717-94-6,62717-42-4
(-)-SKF 38393 hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / 88percent aq. formic acid / 4 h / Heating

3: 1.) cyanogen bromide, 2.) 3N aq. HCl, glacial acetic acid / 1.) benzene, 55-60 deg C, 4 h, 2.) reflux, 24 h

4: 80 percent / aq. HCl / Heating

With hydrogenchloride; formic acid; bromocyane; acetic acid;
DOI:10.1021/jm00086a016