5-N-benzylamino-2-N,N-dimethylaminopyrimidine

Base Information

• Chemical Name: 5-N-benzylamino-2-N,N-dimethylaminopyrimidine
• CAS No.: 1083329-56-9
• Molecular Formula: C₁₃H₁₆N₄
• Molecular Weight: 228.297
• Mol file: 1083329-56-9.mol

Synonyms:5-N-benzylamino-2-N,N-dimethylaminopyrimidine

Chemical Property of 5-N-benzylamino-2-N,N-dimethylaminopyrimidine

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-N-benzylamino-2-N,N-dimethylaminopyrimidine

There total 2 articles about 5-N-benzylamino-2-N,N-dimethylaminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-iodo-N,N-dimethylpyrimidin-2-amine (1083329-41-2) + benzylamine (100-46-9) → 5-N-benzylamino-2-N,N-dimethylaminopyrimidine (1083329-56-9)

Guidance literature:

With potassium phosphate; copper(l) iodide; L-proline; In dimethyl sulfoxide; at 80 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jo801501e

Reference yield: 82.0%

5-bromo-N,N-dimethylpyrimidin-2-amine (38696-21-8) + benzylamine (100-46-9) → 5-N-benzylamino-2-N,N-dimethylaminopyrimidine (1083329-56-9)

Guidance literature:

5-bromo-N,N-dimethylpyrimidin-2-amine; With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; Inert atmosphere;

benzylamine; In dimethyl sulfoxide; at 80 ℃; Inert atmosphere;

DOI:10.1021/jo301013c

Reference yield: 81.0%

5-N-benzylamino-2-N,N-dimethylaminopyrimidine (1083329-56-9) → 5-amino-2-N,N-dimethylaminopyrimidine (56621-99-9)

Guidance literature:

With Pd/C; ammonium formate; In methanol; for 0.5h; Reflux;

DOI:10.1021/jo801501e

upstream raw materials:

5-iodo-N,N-dimethylpyrimidin-2-amine

benzylamine

5-bromo-N,N-dimethylpyrimidin-2-amine

Downstream raw materials:

5-amino-2-N,N-dimethylaminopyrimidine