5-Bromo-2-(dimethylamino)pyrimidine

Base Information

• Chemical Name: 5-Bromo-2-(dimethylamino)pyrimidine
• CAS No.: 38696-21-8
• Molecular Formula: C6H8BrN3
• Molecular Weight: 202.054
• Hs Code.: 2933599090
• European Community (EC) Number: 622-734-6
• DSSTox Substance ID: DTXSID60508471
• Nikkaji Number: J1.216.014C
• Wikidata: Q82365419
• Mol file: 38696-21-8.mol

Synonyms:38696-21-8;5-Bromo-2-(dimethylamino)pyrimidine;5-bromo-N,N-dimethylpyrimidin-2-amine;(5-Bromopyrimidin-2-yl)dimethylamine;MFCD07368228;2-(N,N-dimethylamino)-5-bromopyrimidine;5-Bromo-N,N-Dimethyl-Pyrimidin-2-Amine;5-bromo-2-dimethylaminopyrimidine;SCHEMBL629463;DTXSID60508471;NYMYGNLCILQUMT-UHFFFAOYSA-N;5-bromo-2(dimethylamino)pyrimidine;AKOS013153651;5-bromo-N,N-dimethyl-2-pyrimidinamine;CS-W015524;FS-3167;(5-Bromo-pyrimidin-2-yl)-dimethyl-amine;SY030999;5-bromanyl-N,N-dimethyl-pyrimidin-2-amine;5-Bromo-2-(dimethylamino)pyrimidine, 97%;AM20100027;FT-0645417;EN300-1252608;A824238;J-517179

Chemical Property of 5-Bromo-2-(dimethylamino)pyrimidine

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Melting Point: 74-81°C
• Refractive Index: 1.599
• Boiling Point: 271.959 °C at 760 mmHg
• PKA: 2.21±0.10(Predicted)
• Flash Point: 118.277 °C
• PSA: 29.02000
• Density: 1.554 g/cm³
• LogP: 1.30510
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 200.99016
• Heavy Atom Count: 10
• Complexity: 99.2

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-(dimethylamino)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=NC=C(C=N1)Br

Technology Process of 5-Bromo-2-(dimethylamino)pyrimidine

There total 8 articles about 5-Bromo-2-(dimethylamino)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 5-bromo-N,N-dimethylpyrimidin-2-amine (38696-21-8)

Guidance literature:

Reference yield: 97.0%

5-Bromo-2-chloropyrimidine (32779-36-5) + dimethyl amine (124-40-3) → 5-bromo-N,N-dimethylpyrimidin-2-amine (38696-21-8)

Guidance literature:

In ethanol; at 115 ℃; for 48h;

DOI:10.1021/ml1001932

Reference yield: 90.0%

5-bromo-2-chloropyridine (53939-30-3) + dimethyl amine (124-40-3) → 5-bromo-N,N-dimethylpyrimidin-2-amine (38696-21-8)

Guidance literature:

In water; at 20 ℃; for 5h;

upstream raw materials:

2-(dimethylamino)pyrimidine

5-bromo-2-chloropyridine

dimethyl amine

N,N-dimethylammonium chloride

Downstream raw materials:

N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-amine

N-(3-(2-(Dimethylamino)pyrimid-5-yl)phenyl)-2-amino-4-(1-pyrrolyl)aniline

N-Acetyl 3-(2-(dimethylamino)-5-pyrimidyl)aniline

2-(dimethylamino)-N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)pyrimidine-5-carboxamide