2-benzylamino-5-chloro-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazoline

Base Information

• Chemical Name: 2-benzylamino-5-chloro-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazoline
• CAS No.: 144431-43-6
• Molecular Formula: C₁₆H₁₆ClN₅
• Molecular Weight: 313.79

Synonyms:2-benzylamino-5-chloro-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazoline

Chemical Property of 2-benzylamino-5-chloro-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazoline

Chemical Property:

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Technology Process of 2-benzylamino-5-chloro-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazoline

There total 2 articles about 2-benzylamino-5-chloro-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-benzylamino-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-5(10H)-one (144457-65-8) → 2-benzylamino-5-chloro-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazoline (144431-43-6)

Guidance literature:

With pyridine; trichlorophosphate; at 70 ℃; for 2h;

DOI:10.1002/jhet.5570360515

Reference yield:

N3-benzyl-1H-1,2,4-triazole-3,5-diamine (21505-06-6) → 2-benzylamino-5-chloro-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazoline (144431-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / AcOH / 1 h / Heating

2: 89 percent / POCl₃; pyridine / 2 h / 70 °C

With pyridine; acetic acid; trichlorophosphate; 1: Condensation / 2: Chlorination;

DOI:10.1002/jhet.5570360515

Reference yield: 91.0%

4-(2-AMINOETHYL)MORPHOLINE (2038-03-1) + 2-benzylamino-5-chloro-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazoline (144431-43-6) → N2-benzyl-N9-(2-morpholin-4-yl-ethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b]quinazoline-2,9-diamine

Guidance literature:

With triethylamine; In isopropyl alcohol; for 1h; Heating;

DOI:10.1002/jhet.5570390415

upstream raw materials:

2-benzylamino-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-5(10H)-one

N³-benzyl-1H-1,2,4-triazole-3,5-diamine

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