21505-06-6Relevant articles and documents
Photoresponsive Molecular Switch for Regulating Transmembrane Proton-Transfer Kinetics
Li, Ying,Tse, Edmund C. M.,Barile, Christopher J.,Gewirth, Andrew A.,Zimmerman, Steven C.
, p. 14059 - 14062 (2015)
To control proton delivery across biological membranes, we synthesized a photoresponsive molecular switch and incorporated it in a lipid layer. This proton gate was reversibly activated with 390 nm light (Z-isomer) and then deactivated by 360 nm irradiation (E-isomer). In a lipid layer this stimuli responsive proton gate allowed the regulation of proton flux with irradiation to a lipid-buried O2 reduction electrocatalyst. Thus, the catalyst was turned on and off with the E-to-Z interconversion. This light-induced membrane proton delivery system may be useful in developing any functional device that performs proton-coupled electron-transfer reactions.
Controlling Proton and Electron Transfer Rates to Enhance the Activity of an Oxygen Reduction Electrocatalyst
Gautam, Rajendra P.,Lee, Yi Teng,Herman, Gabriel L.,Moreno, Cynthia M.,Tse, Edmund C. M.,Barile, Christopher J.
, p. 13480 - 13483 (2018/09/25)
An electrochemical approach is developed that allows for the control of both proton and electron transfer rates in the O2 reduction reaction (ORR). A dinuclear Cu ORR catalyst was prepared that can be covalently attached to thiol-based self-assembled monolayers (SAMs) on Au electrodes using azide–alkyne click chemistry. Using this architecture, the electron transfer rate to the catalyst is modulated by changing the length of the SAM, and the proton transfer rate to the catalyst is controlled with an appended lipid membrane modified with proton carriers. By tuning the relative rates of proton and electron transfer, the current density of the lipid-covered catalyst is enhanced without altering its core molecular structure. This electrochemical platform will help identify optimal thermodynamic and kinetic parameters for ORR catalysts and catalysts of other reactions that involve the transfer of both protons and electrons.
SUBSTITUTED 5-METHYL-[1, 2, 4] TRIAZOLO [1,5-A) PYRIMIDIN-2-AMINE COMPOUNDS AS PDE2 INHIBITORS
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Page/Page column 50, (2016/06/01)
The invention provides a chemical entity of Formula (I): (I), wherein R1, R2, R3, and R4, have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma- dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.
A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines
Kalinina, Svetlana A.,Kalinin, Dmitrii V.,Dolzhenko, Anton V.
, p. 5537 - 5540 (2013/09/23)
A new, efficient, catalyst-free, one-pot, three-component method for the synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines using 3,5-diamino-1,2,4-triazoles, cyanamide, and triethyl orthoformate is developed. The reaction proceeds smoothly under microwave-assisted heating. Advantages of the method include using easily available reagents, short reaction times, and operational simplicity.
Synthesis of 5,7-diamino1,2,4 triazolo[1,2-a1,3,5 triazines via annulation of 1,3,5-triazine ring onto 3(5)-amino-1,2,4-triazoles
Dolzhenko, Anton V.,Dolzhenko, Anna V.,Chui, Wai-Keung
, p. 429 - 436 (2008/02/09)
The 5,7-diamino[1,2,4]triazoeo[1,5-a][1,3,5]triazines were synthesized by cyclocondensation of 3(5)-amino-1,2,4-triazoles with cyanoguanidine. The substituted 3(5)-amino-1,2,4-triazoles were prepared from corresponding hydrazides and S-methylisothiourea via ring closure of the intermediate acylaminoguanidines. The 3,5-diamino-1,2,4-triazoles were prepared using partial aminolysis of dimethyl N-cyanodithiocarbonimidate followed by cyclization of the obtained N-substituted N′-cyano-S-methylisothioureas with hydrazine. The structures of the prepared compound were confirmed using NMR spectral data.
Regioselective synthesis of alkyl derivatives of 3,5-diamino-1,2,4-triazole
Chernyshev,Rakitov,Astakhov,Sokolov,Zemlyakov,Taranushich
, p. 624 - 630 (2008/02/05)
New procedures were suggested for regioselective synthesis of alkyl derivatives of 3,5-diamino-1,2,4-triazole. Pleiades Publishing, Inc., 2006.
On Triazoles. V . Synthesis of 1- and 2-R1-3-R2,R3-Amino-5-amino-1,2,4-triazoles
Reiter, Jozsef,Pongo, Laszlo,Somorai, Tamas,Dvortsak, Peter
, p. 401 - 408 (2007/10/02)
The correct isomeric and tautomeric structure of different 1- and 2-R1-3-R2,R3-amino-5-amino-1,2,4-triazole derivatives prepared from the corresponding N-cyano-N'-R2,R3-S-methyl-isothioureas and the corresponding hydrazines was proved with the help of their ir, uv, 1H-nmr and 13C-nmr spectra as well as the uv spectra of the Schiff bases of an isomeric pair.
