1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate

Base Information

• Chemical Name: 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate
• CAS No.: 123642-63-7
• Molecular Formula: C₂₄H₃₆N₂O₁₀
• Molecular Weight: 512.557
• Mol file: 123642-63-7.mol

Synonyms:1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate

Chemical Property of 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate

There total 3 articles about 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4',5'-dimethoxy-2'-nitroacetophenone (4101-32-0) → 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate (123642-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / 85percent hydrazine hydrate, glacial acetic acid / aq. ethanol / 3 h / Heating

2: 1) MnO₂ / 1) CHCl₃, 7 min, 2) 2 days

With manganese(IV) oxide; hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1021/jo00292a038

Reference yield:

1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) → 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate (123642-63-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / HNO₃ conc. / 1 h / 18 - 22 °C

2: 53 percent / 85percent hydrazine hydrate, glacial acetic acid / aq. ethanol / 3 h / Heating

3: 1) MnO₂ / 1) CHCl₃, 7 min, 2) 2 days

With manganese(IV) oxide; nitric acid; hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1021/jo00292a038

Reference yield:

Boc-Glu(OtBu)-OH (13726-84-6) + 4,5-dimethoxy-2-nitroacetophenone hydrazone (123642-61-5) → 1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> 5-tert-butyl N-(tert-butoxycarbonyl)glutamate (123642-63-7)

Guidance literature:

With manganese(IV) oxide; Yield given. Multistep reaction; 1) CHCl₃, 7 min, 2) 2 days;

DOI:10.1021/jo00292a038

upstream raw materials:

Boc-Glu(OtBu)-OH

4,5-dimethoxy-2-nitroacetophenone hydrazone

4',5'-dimethoxy-2'-nitroacetophenone

1-(3,4-dimethoxyphenyl)ethanone

Downstream raw materials:

1-<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl> hydrogen glutamate hydrochloride