tert-Butyl (2-amino-4-methylphenyl)carbamate

Base Information

• Chemical Name: tert-Butyl (2-amino-4-methylphenyl)carbamate
• CAS No.: 885270-81-5
• Molecular Formula: C₁₂H₁₈N₂O₂
• Molecular Weight: 222.287
• Hs Code.: 2924299090
• European Community (EC) Number: 809-543-5
• DSSTox Substance ID: DTXSID80655794
• Wikidata: Q82570071
• Mol file: 885270-81-5.mol

Synonyms:885270-81-5;tert-Butyl (2-amino-4-methylphenyl)carbamate;(2-AMINO-4-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER;TERT-BUTYL N-(2-AMINO-4-METHYLPHENYL)CARBAMATE;SCHEMBL3410364;DTXSID80655794;XNPUCPSCDSDLKP-UHFFFAOYSA-N;MFCD05663970;AB22089;AMY202003245;CS-0341985;FT-0769606;tert-Butyl(2-amino-4-methylphenyl)carbamate;(2-Amino-4-methyl-phenyl)-carbamic acid t-butyl ester;(2-Amino-4-methyl-phenyl)-carbamic acid tert-butyl ester, AldrichCPR

Chemical Property of tert-Butyl (2-amino-4-methylphenyl)carbamate

Chemical Property:

• PSA: 64.35000
• LogP: 3.57840
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 222.136827821
• Heavy Atom Count: 16
• Complexity: 248

Purity/Quality:

97% ^*data from raw suppliers

(2-Amino-4-methyl-phenyl)-carbamicacidtert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)NC(=O)OC(C)(C)C)N

Technology Process of tert-Butyl (2-amino-4-methylphenyl)carbamate

There total 4 articles about tert-Butyl (2-amino-4-methylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-methyl-1,2-diaminobenzene (496-72-0) → 4-N-(tert-butoxycarbonyl)-3,4-diaminotoluene (885270-81-5) + 3-N-(tert-butoxycarbonyl)-3,4-diaminotoluene (885270-77-9)

Guidance literature:

In dichloromethane; water; at 20 ℃;

Reference yield:

tert-butyl (4-methyl-2-nitrophenyl)carbamate (866005-25-6) → 4-N-(tert-butoxycarbonyl)-3,4-diaminotoluene (885270-81-5)

Guidance literature:

With pyridine; tin(ll) chloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2007.10.026

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-N-(tert-butoxycarbonyl)-3,4-diaminotoluene (885270-81-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 - 20 °C

1.2: 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1021/acsmedchemlett.7b00091

upstream raw materials:

tert-butyl (4-methyl-2-nitrophenyl)carbamate

di-tert-butyl dicarbonate

4-methyl-1,2-diaminobenzene

4-methyl-2-nitroaniline

Downstream raw materials:

N-(tert-butyl)-1-(cyclopropanecarbonyl)-6-methyl-3-phenyl-1,4-dihydroquinoxaline-2-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 885270-81-5 (2-AMINO-4-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send