Technology Process of 5-(1-benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-nicotinic acid
There total 6 articles about 5-(1-benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-nicotinic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-nicotinic acid methyl ester; benzyl bromide;
With
sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
at 0 - 50 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 130 °C
2.1: aluminum (III) chloride / benzene / 0 - 20 °C
2.2: 0 °C / Cooling with ice
3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C
4.1: tert-butyl alcohol / 80 °C
4.2: 2 h
4.3: 1 h / 80 °C
5.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane / 80 °C / Inert atmosphere
6.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 0 - 50 °C
With
aluminum (III) chloride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C
2.1: tert-butyl alcohol / 80 °C
2.2: 2 h
2.3: 1 h / 80 °C
3.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane / 80 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 0 - 50 °C
With
sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;
