(4S,5S)-4-benzyl-1,5-bis(tert-butoxycarbonyl)-imidazolidin-2-one

Base Information

• Chemical Name: (4S,5S)-4-benzyl-1,5-bis(tert-butoxycarbonyl)-imidazolidin-2-one
• CAS No.: 128576-69-2
• Molecular Formula: C₂₀H₂₈N₂O₅
• Molecular Weight: 376.453
• Mol file: 128576-69-2.mol

Synonyms:(4S,5S)-4-benzyl-1,5-bis(tert-butoxycarbonyl)-imidazolidin-2-one

Chemical Property of (4S,5S)-4-benzyl-1,5-bis(tert-butoxycarbonyl)-imidazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5S)-4-benzyl-1,5-bis(tert-butoxycarbonyl)-imidazolidin-2-one

There total 1 articles about (4S,5S)-4-benzyl-1,5-bis(tert-butoxycarbonyl)-imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2S,3S)-1-tert-butyl N-(tert-butoxycarbonyl)-3-benzylaspartate (128576-64-7) → (4S,5S)-4-benzyl-1,5-bis(tert-butoxycarbonyl)-imidazolidin-2-one (128576-69-2)

Guidance literature:

With diphenyl-phosphinic acid; triethylamine; In acetonitrile; at 55 ℃; for 16h;

DOI:10.1021/jo00304a011

Reference yield: 94.0%

(4S,5S)-4-benzyl-1,5-bis(tert-butoxycarbonyl)-imidazolidin-2-one (128576-69-2) → (4S,5S)-4-carboxy-5-benzylimidazolidin-2-one (128576-59-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 36h; Ambient temperature;

DOI:10.1021/jo00304a011

Reference yield:

(4S,5S)-4-benzyl-1,5-bis(tert-butoxycarbonyl)-imidazolidin-2-one (128576-69-2) → (2S,3S)-2,3-diamino-4-phenylbutanoic acid dihydrochloride (128576-55-6,128576-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / trifluoroacetic acid / CH₂Cl₂ / 36 h / Ambient temperature

2: 100 percent / aq.HCl / 2.5 h / Heating

With hydrogenchloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo00304a011

upstream raw materials:

(2S,3S)-1-tert-butyl N-(tert-butoxycarbonyl)-3-benzylaspartate

Downstream raw materials:

(4S,5S)-4-carboxy-5-benzylimidazolidin-2-one

(2S,3S)-2,3-diamino-4-phenylbutanoic acid dihydrochloride