128576-64-7Relevant articles and documents
Stereoselective synthesis of β-substituted aspartic acids via tetrahydro-1,3-oxazin-6-ones
Burtin, Guillaume,Corringer, Pierre-Jean,Hitchcock, Peter B.,Young, Douglas W.
, p. 4275 - 4278 (1999)
Oxazinones have been synthesised and used as chiral templates in the synthesis of β-substituted aspartic acids. Use of a Bredereck's reagent/Grignard/hydrogenation strategy gave cis-oxazinones with complete stereoselectivity, whereas an alkylation strategy, although trans-selective, gave mixtures of isomers. The oxazinones could be converted to β-substituted aspartic acids and to regioselectively protected β-substituted aspartic acids without loss of stereochemistry at either centre.
Stereoselective Synthesis of 2,3-Diamino Acids. 2,3-Diamino-4-phenylbutanoic Acid
Dunn, Peter J.,Haener, Robert,Rapoport, Henry
, p. 5017 - 5025 (2007/10/02)
The synthesis of (2S,3S)- and (2S,3R)-2,3-diamino-4-phenylbutanoic acid (1c and 3) from L-aspartic acid is described.The N-(phenylfluorenyl)-protected aspartic acid diesters 4 and 10 (α-tert-butyl, β-methyl), 18 (β-benzyl, α-tert-butyl), and 28 (β-benzyl,