4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl}-2-fluoro-N-methylbenzamide

Base Information

Chemical Name:4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl}-2-fluoro-N-methylbenzamide
CAS No.:1351185-48-2
Molecular Formula:C₂₀H₁₄F₄N₄O₂S
Molecular Weight:450.416
Hs Code.:

Synonyms:4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl}-2-fluoro-N-methylbenzamide

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Chemical Property of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl}-2-fluoro-N-methylbenzamide

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Technology Process of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl}-2-fluoro-N-methylbenzamide

There total 4 articles about 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl}-2-fluoro-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1351185-77-7
N-[4-(methylcarbamoyl)-3-fluorophenyl]-N-{[3-(trifluoromethyl)-4-cyanophenyl]thiocarbamoyl}-β-alanine

: 1351185-48-2
4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl}-2-fluoro-N-methylbenzamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 45 ℃; for 15h;
DOI:10.1016/j.ejmech.2015.05.039

Reference yield:

: 915087-25-1
2-fluoro-N-methyl-4-amino-benzamide

: 1351185-48-2
4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl}-2-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 24 h / 70 °C

2: N,N-dimethyl-formamide / 8 h / 60 °C / Microwave irradiation

3: sodium hydroxide; water / 2 h / 80 °C

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 45 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1351185-74-4
ethyl N-[4-(methylcarbamoyl)-3-fluorophenyl]-β-alaninate

: 1351185-48-2
4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-4-oxo-2-thioxotetrahydropyrimidin-1(2H)-yl}-2-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 8 h / 60 °C / Microwave irradiation

2: sodium hydroxide; water / 2 h / 80 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 45 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In N,N-dimethyl-formamide;