ethyl 2-ethoxycarbonyl-5,5-diphenylpenta-2,3,4-trienoate

Base Information

• Chemical Name: ethyl 2-ethoxycarbonyl-5,5-diphenylpenta-2,3,4-trienoate
• CAS No.: 115349-49-0
• Molecular Formula: C₂₂H₂₀O₄
• Molecular Weight: 348.398
• Mol file: 115349-49-0.mol

Synonyms:ethyl 2-ethoxycarbonyl-5,5-diphenylpenta-2,3,4-trienoate

Chemical Property of ethyl 2-ethoxycarbonyl-5,5-diphenylpenta-2,3,4-trienoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-ethoxycarbonyl-5,5-diphenylpenta-2,3,4-trienoate

There total 1 articles about ethyl 2-ethoxycarbonyl-5,5-diphenylpenta-2,3,4-trienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

(2-bromo-3,3-diphenylprop-2-en-1-yl)triphenylphosphonium bromide (24448-42-8) + Diethyl ketomalonate (609-09-6) → ethyl 2-ethoxycarbonyl-5,5-diphenylpenta-2,3,4-trienoate (115349-49-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; a) RT, 1.5 h, b) from -78 deg C to RT;

Reference yield: 92.0%

ethyl 2-ethoxycarbonyl-5,5-diphenylpenta-2,3,4-trienoate (115349-49-0) + [(4-methyl-benzylidene)-amino]-acetic acid methyl ester → (2R,5R)-4,4-diethyl 2-methyl 3-(2,2-diphenylvinylidene)-5-p-tolylpyrrolidine-2,4,4-tricarboxylate (1309922-99-3)

Guidance literature:

With (S)-TF-Biphamphos; silver(I) acetate; potassium carbonate; In dichloromethane; at 0 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c1ob05291h

Reference yield: 90.0%

methyl 2-(m-methylbenzylideneamino)acetate (943759-24-8) + ethyl 2-ethoxycarbonyl-5,5-diphenylpenta-2,3,4-trienoate (115349-49-0) → (2R,5R)-4,4-diethyl 2-methyl 3-(2,2-diphenylvinylidene)-5-m-tolylpyrrolidine-2,4,4-tricarboxylate (1309923-00-9)

Guidance literature:

With (S)-TF-Biphamphos; silver(I) acetate; potassium carbonate; In dichloromethane; at 0 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c1ob05291h

upstream raw materials:

(2-bromo-3,3-diphenylprop-2-en-1-yl)triphenylphosphonium bromide

Diethyl ketomalonate

Downstream raw materials:

diethyl 3-(2',2'-diphenylethenylidene)bicyclo<2.2.1>hept-5-ene-2,2-dicarboxylate

diethyl 2-(3'-phenyl-1H-inden-1'-ylidene)propane-1,3-dioate

triethyl 3-oxo-3',9-diphenyl-2,3-dihydrospiro<1H-fluorene-1,1'-<1H>indene>-2,2,4-tricarboxylate

3-(2',2'-diphenylethenyl)bicyclo<2.2.1>hepta-2,5-diene-2-carboxylic acid