trans-N-{4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

Base Information

Chemical Name:trans-N-{4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide
CAS No.:1382984-18-0
Molecular Formula:C₂₃H₃₂N₂O₂
Molecular Weight:368.519
Hs Code.:

Synonyms:trans-N-{4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

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Chemical Property of trans-N-{4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

Chemical Property:

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Technology Process of trans-N-{4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

There total 3 articles about trans-N-{4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: trans-4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride

: 64-19-7,77671-22-8
acetic acid

: 1382984-18-0
trans-N-{4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

: 215790-29-7
trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde

: 1382984-18-0
trans-N-{4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 5 h / 20 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4-(1-benzofuran-4-yl)piperidine

: 1382984-18-0
trans-N-{4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 5 h / 20 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;