3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one

Base Information

• Chemical Name: 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one
• CAS No.: 261159-27-7
• Molecular Formula: C₃₄H₃₁N₅O₆
• Molecular Weight: 605.65
• Mol file: 261159-27-7.mol

Synonyms:3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one

Chemical Property of 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one

There total 3 articles about 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 3-(2-deoxy-β-D-erythropentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (87171-83-3) → 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one (261159-27-7)

Guidance literature:

With pyridine; N-ethyl-N,N-diisopropylamine; at 20 ℃; for 18h;

DOI:10.1021/tx990141i

Reference yield:

Guanine hydrochloride (635-39-2) → 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one (261159-27-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. HCl / methanol / 0.5 h / 70 °C

2: 220 mg / 2-(N-morpholino)-ethanesulfonic acid; nucleoside 2-deoxyribosyltransferase (EC 2.4.2.6) / methanol / 2 h / 37 °C / pH 6.0

3: 80 percent / iPr₂NEt; pyridine / 18 h / 20 °C

With pyridine; hydrogenchloride; 4-morpholineethanesulfonic acid; nucleoside 2-deoxyribosyltransferase (EC 2.4.2.6); N-ethyl-N,N-diisopropylamine; In methanol;

DOI:10.1021/tx990141i

Reference yield:

pyrimido[1,2-a]purin-10(3H)-one (103408-45-3) → 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-1,3,4,5,8a-pentaaza-cyclopenta[b]naphthalen-9-one (261159-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 220 mg / 2-(N-morpholino)-ethanesulfonic acid; nucleoside 2-deoxyribosyltransferase (EC 2.4.2.6) / methanol / 2 h / 37 °C / pH 6.0

2: 80 percent / iPr₂NEt; pyridine / 18 h / 20 °C

With pyridine; 4-morpholineethanesulfonic acid; nucleoside 2-deoxyribosyltransferase (EC 2.4.2.6); N-ethyl-N,N-diisopropylamine; In methanol;

DOI:10.1021/tx990141i

upstream raw materials:

4,4'-dimethoxytrityl chloride

3-(2-deoxy-β-D-erythropentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine

Guanine hydrochloride

pyrimido[1,2-a]purin-10(3H)-one