(E)-ethyl 4-(2,3-dichlorophenyl)-5-((hydroxyimino)methyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate

Base Information

Chemical Name:(E)-ethyl 4-(2,3-dichlorophenyl)-5-((hydroxyimino)methyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate
CAS No.:1376615-47-2
Molecular Formula:C₁₇H₁₈Cl₂N₂O₃
Molecular Weight:369.248
Hs Code.:

Synonyms:(E)-ethyl 4-(2,3-dichlorophenyl)-5-((hydroxyimino)methyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate

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Chemical Property of (E)-ethyl 4-(2,3-dichlorophenyl)-5-((hydroxyimino)methyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate

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Technology Process of (E)-ethyl 4-(2,3-dichlorophenyl)-5-((hydroxyimino)methyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate

There total 10 articles about (E)-ethyl 4-(2,3-dichlorophenyl)-5-((hydroxyimino)methyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1376615-46-1
(E)-ethyl 5-((allyloxyimino)methyl)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate

: 1376615-47-2
(E)-ethyl 4-(2,3-dichlorophenyl)-5-((hydroxyimino)methyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate

Guidance literature:: With triethylammonium formate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; for 3h; Reflux;

Reference yield:

: 68064-69-7
(Z)-methyl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate

: 1376615-47-2
(E)-ethyl 4-(2,3-dichlorophenyl)-5-((hydroxyimino)methyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux

2.1: diisobutylaluminium hydride / dichloromethane; hexanes / -78 - 20 °C

2.2: 0.25 h / 20 °C

3.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

4.1: hydroxylamine hydrochloride; pyridine / methanol / 20 °C

5.1: potassium carbonate / acetone / Reflux

6.1: hydrogenchloride; water / tetrahydrofuran / 20 °C

7.1: isopropyl alcohol / Reflux

8.1: triethylammonium formate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 3 h / Reflux

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; water; diisobutylaluminium hydride; triethylammonium formate; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexanes; ethanol; dichloromethane; water; isopropyl alcohol; acetone; toluene;

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1376615-47-2
(E)-ethyl 4-(2,3-dichlorophenyl)-5-((hydroxyimino)methyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / water / 1 h / 20 °C

2: isopropyl alcohol / Reflux

3: triethylammonium formate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 3 h / Reflux

With ammonia; triethylammonium formate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; isopropyl alcohol;