(R)-2-amino-3-(4-trifluoromethoxyphenyl)-N-(3,5-dichlorophenyl)-2-methylpropionamide

Base Information

Chemical Name:(R)-2-amino-3-(4-trifluoromethoxyphenyl)-N-(3,5-dichlorophenyl)-2-methylpropionamide
CAS No.:688756-15-2
Molecular Formula:C₁₇H₁₅Cl₂F₃N₂O₂
Molecular Weight:407.22
Hs Code.:

Synonyms:(R)-2-amino-3-(4-trifluoromethoxyphenyl)-N-(3,5-dichlorophenyl)-2-methylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-amino-3-(4-trifluoromethoxyphenyl)-N-(3,5-dichlorophenyl)-2-methylpropionamide

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Technology Process of (R)-2-amino-3-(4-trifluoromethoxyphenyl)-N-(3,5-dichlorophenyl)-2-methylpropionamide

There total 3 articles about (R)-2-amino-3-(4-trifluoromethoxyphenyl)-N-(3,5-dichlorophenyl)-2-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 688756-14-1
(2R,5R)-2-tert-butyl-3-(3,5-dichloro-phenyl)-5-methyl-1-(2,2,2-trifluoro-acetyl)-5-(4-trifluoromethoxy-benzyl)-imidazolidin-4-one

: 688756-15-2
(R)-2-amino-3-(4-trifluoromethoxyphenyl)-N-(3,5-dichlorophenyl)-2-methylpropionamide

Guidance literature:: (2R,5R)-2-tert-butyl-3-(3,5-dichloro-phenyl)-5-methyl-1-(2,2,2-trifluoro-acetyl)-5-(4-trifluoromethoxy-benzyl)-imidazolidin-4-one; With sodium hydroxide; N-benzyl-trimethylammonium hydroxide; In 1,4-dioxane; at 20 - 40 ℃; for 18h;

With hydrogenchloride; In water; at 50 ℃; for 5h;

Reference yield:

: 1246745-48-1
(2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one

: 688756-15-2
(R)-2-amino-3-(4-trifluoromethoxyphenyl)-N-(3,5-dichlorophenyl)-2-methylpropionamide

Guidance literature:: (2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one; With potassium hydroxide; In isopropyl alcohol; at 50 ℃; for 4h;

With sulfuric acid; In isopropyl alcohol; at 70 ℃; for 2h;

With toluene-4-sulfonic acid;