(2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one

Base Information

Chemical Name:(2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one
CAS No.:1246745-48-1
Molecular Formula:C₂₃H₂₀Cl₂F₆N₂O₃
Molecular Weight:557.32
Hs Code.:

Synonyms:(2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one

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Chemical Property of (2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one

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Technology Process of (2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one

There total 5 articles about (2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 341027-25-6
(2R,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trichloroacetyl)-imidazolidin-4-one

: 1246745-48-1
(2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 5 ℃; for 1.5h; diastereoselective reaction;
DOI:10.1021/ol101960x

Reference yield:

: C₇H₈O₃S*C₉H₁₀Cl₂N₂O

: 1246745-48-1
(2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / ethyl acetate / 0.5 h

1.2: 10.5 h / 17 - 23 °C / Reflux

1.3: 12 h / 50 °C

2.1: 3 h / 0 - 20 °C

3.1: 1.5 h / 0 - 5 °C

With water; sodium hydroxide; In ethyl acetate;
DOI:10.1021/op200175t

Reference yield:

: 302840-63-7
(1R)-[1-(3,5-dichloro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 1246745-48-1
(2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene

2.1: water; sodium hydroxide / ethyl acetate / 0.5 h

2.2: 10.5 h / 17 - 23 °C / Reflux

2.3: 12 h / 50 °C

3.1: 3 h / 0 - 20 °C

4.1: 1.5 h / 0 - 5 °C

With water; sodium hydroxide; In ethyl acetate; toluene;
DOI:10.1021/op200175t