methyl N-[(2,6-dimethyl-3-pyridinyl)methylidene]-D-alloisoleucine

Base Information

• Chemical Name: methyl N-[(2,6-dimethyl-3-pyridinyl)methylidene]-D-alloisoleucine
• CAS No.: 1299957-27-9
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.352
• Mol file: 1299957-27-9.mol

Synonyms:methyl N-[(2,6-dimethyl-3-pyridinyl)methylidene]-D-alloisoleucine

Chemical Property of methyl N-[(2,6-dimethyl-3-pyridinyl)methylidene]-D-alloisoleucine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-[(2,6-dimethyl-3-pyridinyl)methylidene]-D-alloisoleucine

There total 1 articles about methyl N-[(2,6-dimethyl-3-pyridinyl)methylidene]-D-alloisoleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-allo-isoleucine methyl ester (2577-46-0,18869-44-8,42271-58-9,81084-74-4,107998-45-8,118878-53-8) + 2,6-dimethylpyridine-3-carboxaldehyde (650141-20-1) → methyl N-[(2,6-dimethyl-3-pyridinyl)methylidene]-D-alloisoleucine (1299957-27-9)

Guidance literature:

In methanol; 2,2,2-trifluoroethanol; at 40 ℃;

Reference yield:

(2R)-2,3-dihydro-1H-inden-2-yl({[(phenylmethyl)oxy]carbonyl}amino)ethanoic acid (554448-74-7) + methyl N-[(2,6-dimethyl-3-pyridinyl)methylidene]-D-alloisoleucine (1299957-27-9) + 1-benzyloxy-2-isocyanobenzene (86652-64-4) → methyl N-[(2R)-2-(2,3-dihydro-1H-inden-2-yl)-2-({[(phenylmethyl)oxy]-carbonyl}amino)acetyl]-N-[1-(2,6-dimethyl-3-pyridinyl)-2-oxo-2-({2-[(phenylmethyl)oxy]phenyl}amino)ethyl]-D-alloisoleucinate (872599-76-3)

Guidance literature:

In methanol; 2,2,2-trifluoroethanol; at 40 ℃;

Reference yield:

methyl N-[(2,6-dimethyl-3-pyridinyl)methylidene]-D-alloisoleucine (1299957-27-9) → 2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,6-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 2,2,2-trifluoroethanol; methanol / 40 °C

2: hydrogen / palladium on carbon / acetic acid; 2,2,2-trifluoroethanol; methanol / 50 °C

With hydrogen; palladium on carbon; In methanol; 2,2,2-trifluoroethanol; acetic acid;

upstream raw materials:

D-allo-isoleucine methyl ester

2,6-dimethylpyridine-3-carboxaldehyde

Downstream raw materials:

methyl N-[(2R)-2-(2,3-dihydro-1H-inden-2-yl)-2-({[(phenylmethyl)oxy]-carbonyl}amino)acetyl]-N-[1-(2,6-dimethyl-3-pyridinyl)-2-oxo-2-({2-[(phenylmethyl)oxy]phenyl}amino)ethyl]-D-alloisoleucinate