4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-2-methoxy-benzonitrile

Base Information

Chemical Name:4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-2-methoxy-benzonitrile
CAS No.:1272719-08-0
Molecular Formula:C₁₉H₁₇FN₄O₂S
Molecular Weight:384.434
Hs Code.:

Synonyms:4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-2-methoxy-benzonitrile

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Chemical Property of 4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-2-methoxy-benzonitrile

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Technology Process of 4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-2-methoxy-benzonitrile

There total 8 articles about 4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-2-methoxy-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1272719-28-4
C₁₀H₁₃N₃

: 1272719-23-9
C₉H₅FN₂OS

: 1272719-08-0
4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-2-methoxy-benzonitrile

Guidance literature:: C₁₀H₁₃N₃; C₉H₅FN₂OS; In N,N-dimethyl-formamide; at 110 ℃; for 12h; Microwave irradiation;

With water; hydrogenchloride; In ethanol; N,N-dimethyl-formamide; for 1h; Reflux;

Reference yield:

: 801282-00-8
2-fluoro-3-methoxyaniline

: 1272719-08-0
4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-2-methoxy-benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: 1 h / 20 °C

3.1: N,N-dimethyl-formamide / 145 °C / Inert atmosphere

4.1: hydrogenchloride / ethanol; water / 1 h / Reflux

4.2: pH 7 - 8

5.1: water; tetrahydrofuran / 1 h / 20 °C

6.1: N,N-dimethyl-formamide / 12 h / 110 °C / Microwave irradiation

6.2: 1 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 137654-20-7
2-fluoro-3-methoxybenzoic acid

: 1272719-08-0
4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-2-methoxy-benzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; diphenylphosphoranyl azide / toluene / 2 h / 20 °C

1.2: 2 h / Reflux

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2.2: pH 8

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 20 °C

4.1: 1 h / 20 °C

5.1: N,N-dimethyl-formamide / 145 °C / Inert atmosphere

6.1: hydrogenchloride / ethanol; water / 1 h / Reflux

6.2: pH 7 - 8

7.1: water; tetrahydrofuran / 1 h / 20 °C

8.1: N,N-dimethyl-formamide / 12 h / 110 °C / Microwave irradiation

8.2: 1 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;