1-methyl-2-[(4-cyanophenyl)oxymethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(ethoxycarbonylmethyl)-amide

Base Information

Chemical Name:1-methyl-2-[(4-cyanophenyl)oxymethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(ethoxycarbonylmethyl)-amide
CAS No.:211916-29-9
Molecular Formula:C₂₇H₂₄N₄O₄
Molecular Weight:468.512
Hs Code.:

Synonyms:1-methyl-2-[(4-cyanophenyl)oxymethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(ethoxycarbonylmethyl)-amide

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Chemical Property of 1-methyl-2-[(4-cyanophenyl)oxymethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(ethoxycarbonylmethyl)-amide

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Technology Process of 1-methyl-2-[(4-cyanophenyl)oxymethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(ethoxycarbonylmethyl)-amide

There total 5 articles about 1-methyl-2-[(4-cyanophenyl)oxymethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(ethoxycarbonylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82357-48-0
4-methylamino-3-nitro-benzoic acid chloride

: 211916-29-9
1-methyl-2-[(4-cyanophenyl)oxymethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(ethoxycarbonylmethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 20 °C

2: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

3: CDI / tetrahydrofuran / 50 °C

4: AcOH / Heating

With hydrogen; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0109513

Reference yield:

: 41263-74-5
4-(methylamino)-3-nitrobenzoic acid

: 211916-29-9
1-methyl-2-[(4-cyanophenyl)oxymethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(ethoxycarbonylmethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / dimethylformamide / 0.5 h / Heating

2: Et₃N / tetrahydrofuran / 20 °C

3: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

4: CDI / tetrahydrofuran / 50 °C

5: AcOH / Heating

With thionyl chloride; hydrogen; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0109513

Reference yield:

: 429658-94-6
[(4-methylamino-3-nitro-benzoyl)phenyl-amino]acetic acid ethyl ester

: 211916-29-9
1-methyl-2-[(4-cyanophenyl)oxymethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(ethoxycarbonylmethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

2: CDI / tetrahydrofuran / 50 °C

3: AcOH / Heating

With hydrogen; acetic acid; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0109513