(R)-3-(4-(5-(4-(piperidin-1-ylmethyl)phenyl)thiophen-2-yl)-1H-1,2,3-triazol-1-yl)quinuclidine

Base Information

Chemical Name:(R)-3-(4-(5-(4-(piperidin-1-ylmethyl)phenyl)thiophen-2-yl)-1H-1,2,3-triazol-1-yl)quinuclidine
CAS No.:1404051-59-7
Molecular Formula:C₂₅H₃₁N₅S
Molecular Weight:433.621
Hs Code.:

Synonyms:(R)-3-(4-(5-(4-(piperidin-1-ylmethyl)phenyl)thiophen-2-yl)-1H-1,2,3-triazol-1-yl)quinuclidine

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Chemical Property of (R)-3-(4-(5-(4-(piperidin-1-ylmethyl)phenyl)thiophen-2-yl)-1H-1,2,3-triazol-1-yl)quinuclidine

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Technology Process of (R)-3-(4-(5-(4-(piperidin-1-ylmethyl)phenyl)thiophen-2-yl)-1H-1,2,3-triazol-1-yl)quinuclidine

There total 4 articles about (R)-3-(4-(5-(4-(piperidin-1-ylmethyl)phenyl)thiophen-2-yl)-1H-1,2,3-triazol-1-yl)quinuclidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1404051-59-7
(R)-3-(4-(5-(4-(piperidin-1-ylmethyl)phenyl)thiophen-2-yl)-1H-1,2,3-triazol-1-yl)quinuclidine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In methanol; toluene; at 70 ℃; for 0.833333h; Microwave irradiation;

Reference yield: 75.0%

: 859833-22-0
1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]piperidine

: 1403993-19-0
(R)-3-(4-(5-bromothiophen-2-yl)-1H-1,2,3-triazol-1-yl) quinuclidine

: 1404051-59-7
(R)-3-(4-(5-(4-(piperidin-1-ylmethyl)phenyl)thiophen-2-yl)-1H-1,2,3-triazol-1-yl)quinuclidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 150 ℃; for 0.25h; Inert atmosphere; Microwave irradiation; Sealed tube;
DOI:10.1016/j.ejmech.2019.06.049

Reference yield:

: 138500-85-3
4-bromomethylphenylboronic acid pinacol ester

: 1404051-59-7
(R)-3-(4-(5-(4-(piperidin-1-ylmethyl)phenyl)thiophen-2-yl)-1H-1,2,3-triazol-1-yl)quinuclidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 3 h / 20 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In ethanol; toluene; acetonitrile; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2019.06.049