N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl pyrazine-2-carboxamide

Base Information

Chemical Name:N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl pyrazine-2-carboxamide
CAS No.:1223478-11-2
Molecular Formula:C₁₉H₁₄FN₅O
Molecular Weight:347.351
Hs Code.:

Synonyms:N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl pyrazine-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl pyrazine-2-carboxamide

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Technology Process of N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl pyrazine-2-carboxamide

There total 4 articles about N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 5521-55-1
2-methylpyrazin-5-carboxylic acid

: 863869-96-9
2-(4-fluorophenyl)-1H-benzo[d]imidazole-5-amine

: 1223478-11-2
N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl pyrazine-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2011.06.022

Reference yield:

: 348-35-6
2-(4-Fluorophenyl)-6-nitro-1H-benzo[d]imidazole

: 1223478-11-2
N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(ll) chloride / ethanol / 4 h / Inert atmosphere; Reflux

1.2: Inert atmosphere

2.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide / tetrahydrofuran / 20 h / 20 °C

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; diisopropyl-carbodiimide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2011.06.022

Reference yield:

: 99-56-9
4-Nitrophenylene-1,2-diamine

: 1223478-11-2
N-(2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium metabisulfite / N,N-dimethyl-formamide / 15 h / 120 °C / Inert atmosphere

2.1: tin(ll) chloride / ethanol / 4 h / Inert atmosphere; Reflux

2.2: Inert atmosphere

3.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide / tetrahydrofuran / 20 h / 20 °C

With sodium metabisulfite; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; diisopropyl-carbodiimide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.06.022