(-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne

Base Information

Chemical Name:(-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne
CAS No.:205068-06-0
Molecular Formula:C₃₂H₄₁NOSi
Molecular Weight:483.769
Hs Code.:

Synonyms:(-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne

Suppliers and Price of (-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne

There total 8 articles about (-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 591-50-4
iodobenzene

: 205068-03-7
(-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-hexyne

: 205068-06-0
(-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; Ambient temperature;
DOI:10.1016/S0040-4039(98)00085-9

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 205068-06-0
(-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / K₂CO₃, NaOH / H₂O; methanol / Heating

2: 97 percent / LiAlH₄ / tetrahydrofuran / Heating

3: 76 percent / DMAP, Et₃N / CH₂Cl₂ / Heating

4: 90 percent / (COCl)2, DMSO, Et₃N

5: 1.) PPh₃; 2.) n-BuLi / 1.) CH₂Cl₂, 0 deg C; 2.) CH₂Cl₂, -78 deg C -> room temp.

6: 94 percent / CuI, Et₃N / (Ph₃P)2PdCl₂ / Ambient temperature

With dmap; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(98)00085-9

Reference yield:

: 14464-18-7
(2S)-2-(dibenzylamino)pentanedioic acid

: 205068-06-0
(-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / LiAlH₄ / tetrahydrofuran / Heating

2: 76 percent / DMAP, Et₃N / CH₂Cl₂ / Heating

3: 90 percent / (COCl)2, DMSO, Et₃N

4: 1.) PPh₃; 2.) n-BuLi / 1.) CH₂Cl₂, 0 deg C; 2.) CH₂Cl₂, -78 deg C -> room temp.

5: 94 percent / CuI, Et₃N / (Ph₃P)2PdCl₂ / Ambient temperature

With dmap; copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(98)00085-9