14464-18-7

Upstream product

• 56-86-0 L-glutamic acid 
• 100-39-0 benzyl bromide 
• 167905-35-3 (S)-2-dibenzylaminopentanedioic acid dibenzyl ester 
• 617-65-2 Glutamic acid 
• 100-44-7 benzyl chloride 

Downstream Products

• 142784-66-5 (S)-2-(N,N-dibenzylamino)-1,5-pentanediol 
• 205068-01-5 (-)-S-4-(N,N-dibenzylamino)-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate 
• 205068-06-0 (-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-phenyl-1-hexyne 
• 205068-07-1 (-)-S-4-(N,N-dibenzylamino)-6-phenyl-5-hexyn-1-ol 
• 205068-02-6 (-)-S-5-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-pentanal 
• 205068-03-7 (-)-S-6-(tert-butyldimethylsilyloxy)-2-(N,N-dibenzylamino)-1-hexyne 
• 205068-04-8 (S)-2-(N,N-dibenzylamino)-5-(tert-butyldimethylsilyloxy)pentan-1-ol 

Relevant academic research and scientific papers

Synthesis and antiproliferative activity of glutamic acid-based dipeptides

A small and focused library of 22 dipeptides derived from N,N-dibenzylglutamic acid α- and γ-benzyl esters was prepared in a straightforward manner. The evaluation of the antiproliferative activity in the human solid tumor cell lines HBL-100 (breast), HeL

Direct synthesis of polybenzylated glutamic acid monoesters: Disambiguation of N, N -dibenzylglutamic acid α- And γ-benzyl esters

In this study, we explored the regioselective benzylation of l-glutamic acid under substoichiometric amounts of the alkylating agent. Our results demonstrate unambiguously that N,N-dibenzylglutamic acid γ-benzyl ester was not obtained by direct benzylatio

Kilogram synthesis of (S)-3-aminopyran from l -glutamic acid

We describe the development of a concise route to prepare kilogram quantities of (S)-3-aminopyran, a key intermediate in the synthesis of a Jak1 inhibitor. The chiral amine was introduced via a chiral-pool approach and involves using inexpensive, commerci

(-)-Sparteine-mediated stereoselective intramolecular carbolithiation of alkynes

The asymmetric deprotonation mediated by the chiral base s- butyllithium/(-)-sparteine of 4-substituted 5-hexynyl carbamates permits the synthesis of enantioenriched carbanionic pairs which undergo a regioselective 5-exo-dig ring closure with the triple bond acting as an internal electrophile. The functionalized five-membered rings are formed with complete stereoselectivity in high yields.