9-chloro-10-(3-fluoro-benzyloxy)-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Base Information

Chemical Name:9-chloro-10-(3-fluoro-benzyloxy)-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
CAS No.:1347719-51-0
Molecular Formula:C₂₈H₂₇ClFN₃O₅
Molecular Weight:539.991
Hs Code.:

Synonyms:9-chloro-10-(3-fluoro-benzyloxy)-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

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Chemical Property of 9-chloro-10-(3-fluoro-benzyloxy)-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Chemical Property:

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Technology Process of 9-chloro-10-(3-fluoro-benzyloxy)-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

There total 6 articles about 9-chloro-10-(3-fluoro-benzyloxy)-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.39%

: 1347720-94-8
C₂₈H₂₉ClFN₃O₆

: 1347719-51-0
9-chloro-10-(3-fluoro-benzyloxy)-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Guidance literature:: With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; Cooling with ice;

Reference yield: 69.39%

: 1347719-51-0
9-chloro-10-(3-fluoro-benzyloxy)-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Guidance literature:

Reference yield:

: 3943-89-3
Ethyl protocatechuate

: 1347719-51-0
9-chloro-10-(3-fluoro-benzyloxy)-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / 6 h / Reflux

2: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice

3: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C

4: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux

5: acetic acid / isopropyl alcohol / 20 °C

6: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / Cooling with ice

With thionyl chloride; 5%-palladium/activated carbon; nitric acid; ammonium formate; potassium carbonate; acetic acid; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; isopropyl alcohol; acetonitrile;