(1S,2S,3S,5S)-5-AMino-3-(phenylMethoxy)-2-[(phenylMethoxy)Methyl]-cyclopentanol

Base Information

Chemical Name:(1S,2S,3S,5S)-5-AMino-3-(phenylMethoxy)-2-[(phenylMethoxy)Methyl]-cyclopentanol
CAS No.:888015-86-9
Molecular Formula:C₂₀H₂₅NO₃
Molecular Weight:327.423
Hs Code.:
Mol file:888015-86-9.mol

Synonyms:(1S,2S,3S,5S)-5-amino-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

Suppliers and Price of (1S,2S,3S,5S)-5-AMino-3-(phenylMethoxy)-2-[(phenylMethoxy)Methyl]-cyclopentanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1S,2S,3S,5S)-5-Amino-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol
250mg
$ 1320.00

Medical Isotopes, Inc.
(1S,2S,3S,5S)-5-Amino-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol
250 mg
$ 2200.00

Medical Isotopes, Inc.
(1S,2S,3S,5S)-5-Amino-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol
25 mg
$ 650.00

Total 1 raw suppliers

Chemical Property of (1S,2S,3S,5S)-5-AMino-3-(phenylMethoxy)-2-[(phenylMethoxy)Methyl]-cyclopentanol

Chemical Property:

Solubility.:Dichloromethane

Purity/Quality:: (1S,2S,3S,5S)-5-Amino-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (1S,2S,3S,5S)-5-Amino-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol is a reactant used in the preparation of Entecavir (E558900).

Technology Process of (1S,2S,3S,5S)-5-AMino-3-(phenylMethoxy)-2-[(phenylMethoxy)Methyl]-cyclopentanol

There total 1 articles about (1S,2S,3S,5S)-5-AMino-3-(phenylMethoxy)-2-[(phenylMethoxy)Methyl]-cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 110567-23-2
(1S,2S,3S,5S)-5-azido-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

: 888015-86-9
(1S,2S,3S,5S)-5-amino-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; water; at 20 ℃; for 5h;
DOI:10.1002/jlcr.1664

Reference yield: 82.0%

: 888015-86-9
(1S,2S,3S,5S)-5-amino-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 888015-87-0
(1S,2S,3S,5S)-5-(2-amino-6-chloropyrimidin-4-yl)amino-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

Guidance literature:: With triethylamine; In butan-1-ol; at 115 ℃;
DOI:10.1002/jlcr.955

Reference yield:

: 888015-86-9
(1S,2S,3S,5S)-5-amino-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

: 888015-90-5
2-amino-4-methoxy-6-[(1α,2β,3α,4β)-2-hydroxy-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]amino-5-aminopyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / triethylamine / butan-1-ol / 115 °C

2.1: NaNO₂; HCl / H₂O / 0.5 h / 0 °C

2.2: 91 percent / KOAc; acetic acid / H₂O; acetonitrile / 24 h / 20 °C

3.1: 78 percent / KOH / H₂O / 2 h / 80 °C

4.1: 77 percent / acetic acid; zinc / methanol; H₂O / 2 h / 80 °C

With hydrogenchloride; potassium hydroxide; acetic acid; triethylamine; zinc; sodium nitrite; In methanol; water; butan-1-ol;
DOI:10.1002/jlcr.955