diethyl 3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne phosphonate

Base Information

Chemical Name:diethyl 3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne phosphonate
CAS No.:151899-71-7
Molecular Formula:C₂₈H₂₈N₃O₃P
Molecular Weight:485.522
Hs Code.:

Synonyms:diethyl 3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne phosphonate

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Chemical Property of diethyl 3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne phosphonate

Chemical Property:

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Technology Process of diethyl 3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne phosphonate

There total 6 articles about diethyl 3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl acetate n-hexane

: 107-19-7
propargyl alcohol

: 151899-62-6
3-iodo-1-trityl-1H-1,2,4-triazole

: 151899-79-5
1-hydroxy-3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne

: 151899-71-7
diethyl 3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne phosphonate

Guidance literature:: With copper(I) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;

Reference yield:

: 31250-99-4
1-triphenylmethyl-1,2,4-triazole

: 151899-71-7
diethyl 3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne phosphonate

Guidance literature:: Multi-step reaction with 6 steps

1: n-BuLi; Me₂N(CH₂)2NMe₂; I₂ / tetrahydrofuran

2: PPh₃*HBr / CH₂Cl₂

3: Et₃N; CuI / (Ph₃P)4Pd / dimethylformamide

4: PPh₃; Br₂; Et₃N / CH₂Cl₂

5: NaI / acetone

6: CH₂Cl₂

With copper(l) iodide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; bromine; iodine; triphenylphosphine hydrobromide; triethylamine; triphenylphosphine; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; 1: Iodination / 2: Rearrangement / 3: Substitution / 4: Bromination / 5: Iodination / 6: Substitution;
DOI:10.1002/(SICI)1096-9063(199708)50:4<297::AID-PS592>3.0.CO;2-2

Reference yield:

: 151899-62-6
3-iodo-1-trityl-1H-1,2,4-triazole

: 151899-71-7
diethyl 3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N; CuI / (Ph₃P)4Pd / dimethylformamide

2: PPh₃; Br₂; Et₃N / CH₂Cl₂

3: NaI / acetone

4: CH₂Cl₂

With copper(l) iodide; bromine; triethylamine; triphenylphosphine; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; acetone; 1: Substitution / 2: Bromination / 3: Iodination / 4: Substitution;
DOI:10.1002/(SICI)1096-9063(199708)50:4<297::AID-PS592>3.0.CO;2-2