31250-99-4

Usage

Uses

Used in Pharmaceutical Industry:
1-TRITYL-1H-1,2,4-TRIAZOLE is used as a pharmaceutical agent for its antifungal and anticancer properties. Its unique chemical structure allows it to target specific biological pathways, making it a potential candidate for the development of new drugs to combat fungal infections and cancer.
Used in Agrochemical Industry:
1-TRITYL-1H-1,2,4-TRIAZOLE is utilized as an agrochemical agent, leveraging its antifungal properties to protect crops from various fungal diseases. Its application in this industry can contribute to increased crop yields and reduced crop losses due to fungal infections.
Used in Materials Science:
1-TRITYL-1H-1,2,4-TRIAZOLE is employed in materials science for its unique chemical structure and properties. Its stability and solubility characteristics make it a valuable component in the development of new materials with specific properties, such as improved resistance to fungal degradation or enhanced performance in certain applications.

Upstream product

• 288-88-0 1,2,4-Triazole 
• 76-83-5 trityl chloride 

Downstream Products

• 146097-08-7 1-trityl-1H-1,2,4-triazole-5-carbaldehyde 
• 146097-19-0 diethyl 3-hydroxy-3(1-trityl-1,2,4-triazol-5-yl)propane phosphonate 
• 151899-61-5 1-trityl-5-iodo-1,2,4-triazole 
• 151899-77-3 1-trityl-5-bromo-1,2,4-triazole 
• 151899-63-7 3-bromo-1-trytil-1H-1,2,4-triazole 
• 1555938-30-1 (E)-ethyl 3-(1-trityl-1H-1,2,4-triazol-5-yl)acrylate 
• 1555940-48-1 (Z)-ethyl 3-(1-trityl-1H-1,2,4-triazol-5-yl)acrylate 
• 194999-44-5 [3-Methoxy-3-(2-trityl-2H-[1,2,4]triazol-3-yl)-cyclobutyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Method for synthesizing 1 - methyl - 1H -1, 2 and 4 - triazol -3 - methyl formate

The invention discloses a synthetic 1 - methyl - 1H -1. The invention discloses a method for 2,4 - triazole -3 - methyl formate and belongs to the technical field of organic synthesis. The reaction of 1,2 and 4 - triazole as a raw material is followed by

TRICYCLIC COMPOUNDS AS INHIBITORS OF IMMUNOSUPPRESSION MEDIATED BY TRYPTOPHAN METABOLIZATION

Presently provided are inhibitors of IDO and TDO and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.

Synthesis, SAR and selectivity of 2-acyl- and 2-cyano-1-hetarylalkyl- guanidines at the four histamine receptor subtypes: A bioisosteric approach

In the search for potential bioisosteres of the 4-imidazolyl ring in acylguanidines (e.g. UR-AK24), known to possess affinity to several histamine receptor subtypes (HxR, x = 1-4), and cyanoguanidine-type H 4R agonists (e.g. UR-PI376

Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives

This study describes the design, synthesis and evaluation of a novel series of 1,2,4-triazole and benzotriazole derivatives as inhibitors of cytochrome P450 14α-demethylase (14DM). The chemical structures of the new compounds were confirmed by elemental a

Aromatic heterocycle compounds having HIV integrase inhibiting activities

A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORAwherein RAis hydrogen or ester residue, —CONRBRCwherein RBand RCeach is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A1is optionally substituted heteroaryl; provided that a compound wherein Y and/or A1is optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.

INTEGRASE INHIBITORS CONTAINING AROMATIC HETEROCYCLE DERIVATIVES

A compound of the formula (I): whereinX is hydroxy or the like;Y is -C(=R2)-R3-R4 wherein R2 and R3 is oxygen atom or the like, R4 is hydrogen, optionally substituted alkyl, optionally subs

An investigation into the alkylation of 1,2,4-triazole

The alkylation of 1,2,4-triazole with 4-nitrobenzyl halides and a variety of bases afforded the 1- and 4-alkylated isomers with a consistent regioselectivity of 90:10. Previously reported regiospecific alkylations of 1,2,4-triazole were re-examined and the quoted isomer ratios were shown to depend on the isolation procedure. The use of DBU as base in the alkylation of 1,2,4-triazole allows for a convenient and high yielding synthesis of 1- substituted-1,2,4-triazoles. (C) 2000 Elsevier Science Ltd.

Synthesis of novel cyclobutylphosphonic acids as inhibitors of imidazole glycerol phosphate dehydratase

Diethyl 3-oxocyclobutylphosphonate (5) has been synthesised via a novel one-pot cyclisation reaction of the α-phenylsulphonyl-γ,δ-epoxyphosphonate 8. Addition of 5-lithio-1-trityl-1,2,4-triazole to ketone 5 and deprotection then afforded cis-3-hydroxy-3-(1,2,4-triazol-3-yl])cyclobutylphosphonic acid (cis-4) which showed modest in vitro inhibition of the enzyme imidazole glycerol phosphate dehydratase. In an attempt to obtain the corresponding trans isomer (trans-4), whose inhibitory activity was anticipated to he higher, an efficient three-step synthesis was developed employing base-mediated cyclisation of the γ,δ-epoxy-γ-(1,2,4-triazol-5-yl)phosphonate 35. Although this latter route stereoselectively afforded cis-36, an efficient epimerisation reaction could be subsequently used to obtain the desired trans stereochemistry. However, all attempts at deprotection of trans-36 proceeded with simultaneous re-epimerisation to give the previously prepared cis-4. High level ab initio calculations have been used to rationalise the relative thermodynamic stability of cis-4 and trans-4.

Triazole phosphoric acid derivatives and their use as herbicides

A herbicidal compound of formula (I) STR1 or a salt, tautomer or cyclic derivative thereof; where R1 and R2 are hydrogen and A is an optionally substituted saturated or unsaturated chain or ring of three carbon atoms. Methods for pre

An improved method for the N-alkylation of benzotriazole and 1,2,4-triazole

The N-alkylation of benzotriazole and 1,2,4-triazole with alkyl halides proceeds efficiently in the presence of sodium hydroxide in N,N-dimethylformamide.