N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-nitro-4,5-dichlorophenylacetamide

Base Information

• Chemical Name: N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-nitro-4,5-dichlorophenylacetamide
• CAS No.: 157947-91-6
• Molecular Formula: C₂₁H₂₃Cl₂N₃O₃
• Molecular Weight: 436.338
• Mol file: 157947-91-6.mol

Synonyms:N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-nitro-4,5-dichlorophenylacetamide

Chemical Property of N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-nitro-4,5-dichlorophenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-nitro-4,5-dichlorophenylacetamide

There total 4 articles about N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-nitro-4,5-dichlorophenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridine (110-86-1) + 2-nitro-4,5-dichlorophenylacetic acid (37777-90-5) → N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-nitro-4,5-dichlorophenylacetamide (157947-91-6)

Guidance literature:

With ammonia; benzotriazol-1-ol; In methanol;

Reference yield:

2-nitro-4,5-dichlorophenylacetic acid (37777-90-5) + (1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine (116508-51-1) → N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-nitro-4,5-dichlorophenylacetamide (157947-91-6)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) CH₂Cl₂, 25 deg C, 2 min, 2.) CH₂Cl₂, 12 h;

DOI:10.1021/jm00044a006

Reference yield:

→ N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-nitro-4,5-dichlorophenylacetamide (157947-91-6)

Guidance literature:

upstream raw materials:

2-nitro-4,5-dichlorophenylacetic acid

(1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine

pyridine

Downstream raw materials:

N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-amino-4,5-dichlorophenylacetamide