[1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Base Information

Chemical Name:[1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine
CAS No.:133421-03-1
Molecular Formula:C₁₈H₂₆N₂O₃
Molecular Weight:318.416
Hs Code.:

Synonyms:[1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

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Chemical Property of [1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

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Technology Process of [1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

There total 5 articles about [1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130796-32-6
(4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde

: 72748-99-3,187035-29-6
(R)-1-Amino-2-(methoxymethyl)pyrrolidine

: 133421-03-1
[1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Guidance literature:: In dichloromethane; for 18h; Yield given; Ambient temperature;

Reference yield:

: 56503-11-8,56503-12-9,108741-11-3,108741-12-4,108741-13-5,108741-14-6,123725-06-4
ethyl (3R)-2,3-dihydroxy-3-phenylpropanoate

: 133421-03-1
[1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: HC(OEt)3 / 24 h / Ambient temperature

2: 1) (iBu)2AlH ⁽⁵⁾, 2) H₂O/Et₂O / 1) heptane, toluene, 18 h, -78 degC, 2) 30 min, r.t.

3: CH₂Cl₂ / 18 h / Ambient temperature

With diethyl ether; water; diisobutylaluminium hydride; orthoformic acid triethyl ester; In dichloromethane;

Reference yield:

: 5695-95-4,16088-08-7,55449-78-0,55449-79-1,56816-80-9,56816-81-0,60209-23-6,70094-91-6,73610-80-7
(R)-2,3-Dihydroxy-3-phenyl-propionic acid

: 133421-03-1
[1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: conc.H₂SO₄, HC(OEt)3 / 48 h / Ambient temperature

2: HC(OEt)3 / 24 h / Ambient temperature

3: 1) (iBu)2AlH ⁽⁵⁾, 2) H₂O/Et₂O / 1) heptane, toluene, 18 h, -78 degC, 2) 30 min, r.t.

4: CH₂Cl₂ / 18 h / Ambient temperature

With diethyl ether; sulfuric acid; water; diisobutylaluminium hydride; orthoformic acid triethyl ester; In dichloromethane;