(4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde

Base Information

• Chemical Name: (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde
• CAS No.: 130796-32-6
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.241
• Mol file: 130796-32-6.mol

Synonyms:(4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde

Chemical Property of (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde

There total 20 articles about (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4S,5R)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyl-1,3-dioxolane (133520-57-7) → (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde (130796-32-6)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1055/s-2006-942467

Reference yield: 94.0%

(4S,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester (214194-15-7) → (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde (130796-32-6)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 5h; Inert atmosphere;

Reference yield: 57.0%

(4S,5R)-trans-4--2,2-dimethyl-5-phenyl-1,3-dioxolan (130796-29-1) → (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde (130796-32-6)

Guidance literature:

With boron trifluoride diethyl etherate; mercury(II) oxide; In tetrahydrofuran; water; for 1h; Ambient temperature;

upstream raw materials:

(4R,5R)-cis-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde

(4S,5R)-trans-4--2,2-dimethyl-5-phenyl-1,3-dioxolan

(4S,5R)-Ethyl 2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylate

(4S,5R)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyl-1,3-dioxolane

Downstream raw materials:

[1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

(4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid

(S)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-en-1-ol

(R)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-en-1-ol