methyl-3-(2-fluorophenyl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxylate

Base Information

Chemical Name:methyl-3-(2-fluorophenyl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxylate
CAS No.:1428640-01-0
Molecular Formula:C₂₇H₂₀FNO₄
Molecular Weight:441.459
Hs Code.:

Synonyms:methyl-3-(2-fluorophenyl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxylate

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Chemical Property of methyl-3-(2-fluorophenyl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxylate

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Technology Process of methyl-3-(2-fluorophenyl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxylate

There total 11 articles about methyl-3-(2-fluorophenyl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428639-99-9
methyl 3-(2-fluorophenyl)-9-methoxy-8-(trifluoromethylsulfonyloxy)-6H-benzo[c]chromene-2-carboxylate

: 1692-25-7
3-pyridylboronic acid

: 1428640-01-0
methyl-3-(2-fluorophenyl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1428639-86-4
methyl 2'-fluoro-5-nitrobiphenyl-2-carboxylate

: 1428640-01-0
methyl-3-(2-fluorophenyl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: iron; acetic acid / 2 h / 85 °C

2: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

3: potassium carbonate / acetone / 4 h / Reflux

4: bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; potassium acetate / 40 h / 100 °C / Inert atmosphere

5: aluminum (III) chloride / dichloromethane / 2 h / 0 °C

6: triethylamine / dichloromethane / 0.75 h / 0 °C

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl acetamide; sulfuric acid; water; potassium acetate; iron; potassium carbonate; acetic acid; triethylamine; sodium nitrite; In 1,2-dimethoxyethane; dichloromethane; water; acetone; 4: |Sonogashira Cross-Coupling / 7: |Suzuki Coupling;

Reference yield:

: 1428639-87-5
methyl 5-amino-2'-fluorobiphenyl-2-carboxylate

: 1428640-01-0
methyl-3-(2-fluorophenyl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

2: potassium carbonate / acetone / 4 h / Reflux

3: bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; potassium acetate / 40 h / 100 °C / Inert atmosphere

4: aluminum (III) chloride / dichloromethane / 2 h / 0 °C

5: triethylamine / dichloromethane / 0.75 h / 0 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl acetamide; sulfuric acid; water; potassium acetate; potassium carbonate; triethylamine; sodium nitrite; In 1,2-dimethoxyethane; dichloromethane; water; acetone; 3: |Sonogashira Cross-Coupling / 6: |Suzuki Coupling;