3-cyclopropyl-1-(4-(6-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione

Base Information

• Chemical Name: 3-cyclopropyl-1-(4-(6-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione
• CAS No.: 1228660-00-1
• Molecular Formula: C₂₃H₂₅FN₄O₄S
• Molecular Weight: 472.54
• Mol file: 1228660-00-1.mol

Synonyms:3-cyclopropyl-1-(4-(6-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione

Chemical Property of 3-cyclopropyl-1-(4-(6-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-cyclopropyl-1-(4-(6-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione

There total 11 articles about 3-cyclopropyl-1-(4-(6-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(6-bromo-3-fluoropyridin-2-ylmethyl)thiomorpholine 1,1-dioxide (1228660-62-5) + C19H25BN2O4 → 3-cyclopropyl-1-(4-(6-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione (1228660-00-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; at 75 ℃; for 17h; Inert atmosphere;

DOI:10.1021/jm200916p

Reference yield:

6-bromo-3-fluoropyridine-2-carbaldehyde (885267-36-7) → 3-cyclopropyl-1-(4-(6-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione (1228660-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 0.25 h / 10 °C

1.2: 2 h / 5 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 17 h / 75 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; dichloromethane; water; toluene; 2.1: Suzuki coupling;

DOI:10.1021/jm200916p

Reference yield:

1-(4-bromobenzyl)-3-cyclopropylimidazolidine-2,4-dione (1228594-48-6) → 3-cyclopropyl-1-(4-(6-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione (1228660-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 17 h / 75 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 17 h / 75 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;

DOI:10.1021/jm200916p

upstream raw materials:

1-(4-bromobenzyl)-3-cyclopropylimidazolidine-2,4-dione

2-(4-bromo-benzylamino)-N-cyclopropyl-acetamide

6-bromo-3-fluoropyridine-2-carbaldehyde

4-(6-bromo-3-fluoropyridin-2-ylmethyl)thiomorpholine 1,1-dioxide