N²-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-N¹-(1-cyanocyclopropyl)-L-leucinamide

Base Information

• Chemical Name: N²-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-N¹-(1-cyanocyclopropyl)-L-leucinamide
• CAS No.: 603142-88-7
• Molecular Formula: C₁₈H₂₂BrF₂N₃O
• Molecular Weight: 414.293

Synonyms:N²-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-N¹-(1-cyanocyclopropyl)-L-leucinamide

Chemical Property of N²-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-N¹-(1-cyanocyclopropyl)-L-leucinamide

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Technology Process of N²-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-N¹-(1-cyanocyclopropyl)-L-leucinamide

There total 1 articles about N²-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-N¹-(1-cyanocyclopropyl)-L-leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-L-leucine + 1-amino-1-cyclopropanecarbonitrile hydrochloride (127946-77-4) → N2-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-N1-(1-cyanocyclopropyl)-L-leucinamide (603142-88-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); for 16h;

Reference yield:

N2-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-N1-(1-cyanocyclopropyl)-L-leucinamide (603142-88-7) + bis(pinacol)diborane (73183-34-3) → N1-(1-cyanocyclopropyl)-N2-{(1S)-2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}-L-leucinamide (847359-01-7)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 16h;

Reference yield:

N2-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-N1-(1-cyanocyclopropyl)-L-leucinamide (603142-88-7) + (4-thiomethoxyphenyl)boronic acid (98546-51-1) → N1-(1-cyanocyclopropyl)-N2-{(1S)-2,2-difluoro-1-[4'-(methylthio)-1,1'-biphenyl-4-yl]ethyl}-L-leucinamide

Guidance literature:

With sodium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In DMF (N,N-dimethyl-formamide); water; at 80 ℃; for 4h;

upstream raw materials:

1-amino-1-cyclopropanecarbonitrile hydrochloride

Downstream raw materials:

N₁-(1-cyanocyclopropyl)-N₂-{(1S)-2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}-L-leucinamide

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