tert-butyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorobenzylcarbamate

Base Information

• Chemical Name: tert-butyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorobenzylcarbamate
• CAS No.: 1338473-81-6
• Molecular Formula: C₂₂H₁₉Cl₂F₅N₂O₃
• Molecular Weight: 525.302
• Mol file: 1338473-81-6.mol

Synonyms:tert-butyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorobenzylcarbamate

Chemical Property of tert-butyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorobenzylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorobenzylcarbamate

There total 6 articles about tert-butyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorobenzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1,3-dichloro-2-fluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (928783-84-0) + tert-butyl{2-fluoro-5-[(E/Z)-(hydroxyimino)methyl]-benzyl}-carbamate (1338473-75-8) → tert-butyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorobenzylcarbamate (1338473-81-6)

Guidance literature:

tert-butyl{2-fluoro-5-[(E/Z)-(hydroxyimino)methyl]-benzyl}-carbamate; With N-chloro-succinimide; In N,N-dimethyl-formamide; for 14.8333h; Inert atmosphere;

1,3-dichloro-2-fluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene; With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

2-(3,5-dichloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1092485-88-5) → tert-butyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorobenzylcarbamate (1338473-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 18 h / 80 °C / Reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 14.83 h / Inert atmosphere

2.2: 24 h / 20 °C

With N-chloro-succinimide; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

tert-butyl (2-fluoro-5-formylbenzyl)carbamate (334018-67-6) → tert-butyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorobenzylcarbamate (1338473-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 4 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 14.83 h / Inert atmosphere

2.2: 24 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl (2-fluoro-5-formylbenzyl)carbamate

di-tert-butyl dicarbonate

(5-bromo-2-fluoro-phenyl)methanamine hydrochloride

tert-butyl 5-bromo-2-fluorobenzylcarbamate

Downstream raw materials:

2-cyclopropyl-N-{5-[5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}acetamide

(5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorophenyl)methanamine