928783-84-0

Usage

Functional groups

Chlorine atoms (3), Fluorine atom (1), Benzene ring, 3,3,3-trifluoroprop-1-en-2-yl group

Structural features

a. Chlorine atoms are attached to the 1st and 3rd carbon atoms of the benzene ring
b. Fluorine atom is attached to the 2nd carbon atom of the benzene ring
c. 3,3,3-trifluoroprop-1-en-2-yl group is attached to the 5th carbon atom of the benzene ring

Physical properties

a. Likely to be a solid at room temperature due to the presence of multiple halogen atoms
b. May have a high melting point due to strong intermolecular forces
c. Low solubility in water due to the presence of nonpolar groups
d. High solubility in organic solvents like dichloromethane or acetone

Chemical properties

a. Reactive towards nucleophiles due to the presence of electron-withdrawing groups
b. Susceptible to electrophilic aromatic substitution reactions at the unsubstituted carbon atoms of the benzene ring
c. May undergo halogenation reactions with other halogens
d. Potential for hydrogen bonding with polar solvents due to the presence of fluorine atoms

Potential applications

a. Building block in organic synthesis
b. Development of pharmaceuticals
c. Development of agrochemicals
d. Development of materials science

Safety considerations

a. Handle with care due to potential reactivity
b. Thorough investigation of properties before industrial or commercial applications
c. Use appropriate protective equipment and follow safety protocols during handling and storage

Upstream product

• 17318-08-0 5-bromo-1,3-dichloro-2-fluorobenzene 
• 1514-82-5 2-bromo-3,3,3-trifluoropropene 
• 1646614-31-4 (3,5-dichloro-4-fluorophenyl)boronic acid 
• 2268-05-5 1,3-dichloro-2-fluorobenzene 
• 1092485-88-5 2-(3,5-dichloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 1092485-96-5 5-[5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile 
• 1367283-12-2 methyl 4-[5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenecarboxylate 
• 1332698-41-5 4-[5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid 
• 1575837-05-6 tert-butyl 6'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1'H-spiro[azetidine-3,3'-furo[3,4-c]pyridine]-1-carboxylate 
• 1575836-90-6 tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate 
• 1575810-97-7 1-benzyl-3-(3,5-dichloro-4-fluoro-phenyl)-3-trifluoromethyl-pyrrolidine 
• 1437779-50-4 (S)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol 
• 1437779-51-5 (R)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol 
• 1437779-30-0 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethyl-benzo[c][1,2]oxaborol-1(3H)-ol 
• 1092485-68-1 5-[5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile 
• 1338473-81-6 tert-butyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorobenzylcarbamate 
• 1338473-82-7 (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-fluorophenyl)methanamine 
• 1338473-66-7 2-cyclopropyl-N-{5-[5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzyl}acetamide 

Relevant academic research and scientific papers

Substituted benzamide isoxazoline derivative or pesticide acceptable salt, composition and application of substituted benzamide isoxazoline derivative or pesticide acceptable salt

The invention belongs to the field of pesticides, and particularly relates to a substituted benzamide isoxazoline derivative or a pesticide acceptable salt, a composition and application thereof, the compound has a structure as shown in a formula (I), and the definition of each group in the formula is shown in the specification. The substituted benzamide isoxazoline derivatives of the present invention have higher insecticidal or acaricidal activity than known compounds.

A substituted benzamide isoxazoline derivative or a salt thereof as a pesticidally acceptable salt. Composition and use thereof

The invention belongs to the field of pesticides, and particularly relates to a substituted benzamide isoxazoline derivative or a salt, composition and application thereof as a pesticide acceptable salt, and the compound has the structure of the formula (

Isoxazoline substituted benzamide derivative as well as preparation method and application thereof

The invention belongs to the technical field of insecticides and acaricides, and particularly relates to an isoxazoline substituted benzamide derivative as well as a preparation method and applicationthereof. The invention particularly provides a compound shown as a formula (I) or salt thereof. The compound shown as the formula (I) has good activity on various pests and mites in agriculture or other fields. Moreover, the compounds can achieve a very good prevention and treatment effect at a very low dosage, so that the compounds can be used for preparing insecticides and/or acaricides, and have a relatively good application prospect.

BORON-CONTAINING SMALL MOLECULES

This invention provides novel compounds, methods of using the compounds, and pharmaceutical formulations comprising the compounds.

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.

SUBSTITUTED ISOXAZOLINE DERIVATIVES

This invention recites substituted isoxazoline derivatives of Formula (1) or a veterinarily acceptable salt thereof, with parasiticidal activity, compositions thereof, and their use as a parasiticide in animals or birds where R1a, R1b/sup

PYRAZOLE-SUBSTITUTED ISOXAZOLINE INSECTICIDES

Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, wherein R1 is F, Cl, Br, CF3, OCHF2, OCF3 or OCH2CF3; R2 is H, F, Cl, Br, CHsub

3-CYANO-4-TRIAZOLYL PHENYLISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS

Disclosed are compounds of Formula 1, N-oxides, and salts thereof; Formula (I) wherein R1 is F, Cl, Br, cyano, CF3, OCF2H, OCF3 or OCH2CF3; R2 is H, F, Cl, Br, CH3, cy