1-[2-Methoxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethanone

Base Information

• Chemical Name: 1-[2-Methoxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethanone
• CAS No.: 136257-62-0
• Molecular Formula: C₁₄H₁₈O₄
• Molecular Weight: 250.295
• DSSTox Substance ID: DTXSID001182750
• Mol file: 136257-62-0.mol

Synonyms:DTXSID001182750;1-[2-Methoxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethanone;136257-62-0

Chemical Property of 1-[2-Methoxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethanone

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 250.12050905
• Heavy Atom Count: 18
• Complexity: 279

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=C(C=CC=C1OC2CCCCO2)OC

Technology Process of 1-[2-Methoxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethanone

There total 3 articles about 1-[2-Methoxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-hydroxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]acetophenone (63854-17-1) + methyl iodide (74-88-4) → 2'-methoxy-6'-tetrahydropyranyloxyacetophenone (136257-62-0)

Guidance literature:

With potassium carbonate; In acetone; for 140h; Heating;

DOI:10.1016/S0040-4020(01)80960-1

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 2'-methoxy-6'-tetrahydropyranyloxyacetophenone (136257-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / p-TsOH / dioxane / 20 h

2: 94 percent / K₂CO₃ / acetone / 140 h / Heating

With potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; acetone;

DOI:10.1016/S0040-4020(01)80960-1

Reference yield:

2,6-dihydroxylacetophenone (699-83-2) → 2'-methoxy-6'-tetrahydropyranyloxyacetophenone (136257-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / p-TsOH / dioxane / 20 h

2: 94 percent / K₂CO₃ / acetone / 140 h / Heating

With potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; acetone;

DOI:10.1016/S0040-4020(01)80960-1

upstream raw materials:

2-hydroxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]acetophenone

methyl iodide

3,4-dihydro-2H-pyran

2,6-dihydroxylacetophenone

Downstream raw materials:

2'-methoxy-4-methyl-6'-tetrahydropyranyloxychalcone

2'-hydroxy-6'-methoxychalcone epoxide

2'-methoxy-4-nitro-6'-tetrahydropyranyloxychalcone epoxide

2-trifluoromethyl-2'-methoxy-6'-tetrahydropyranyloxychalcone epoxide