N-[4-bromo-3-(methyloxy)phenyl]-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide

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Chemical Name:N-[4-bromo-3-(methyloxy)phenyl]-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide
CAS No.:1332333-40-0
Molecular Formula:C₁₈H₂₃BrN₄O₄
Molecular Weight:439.309
Hs Code.:

Synonyms:N-[4-bromo-3-(methyloxy)phenyl]-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide

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Chemical Property of N-[4-bromo-3-(methyloxy)phenyl]-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide

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Technology Process of N-[4-bromo-3-(methyloxy)phenyl]-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide

There total 4 articles about N-[4-bromo-3-(methyloxy)phenyl]-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1332333-18-2
2-[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetohydrazide

: 19056-40-7
4-bromo-3-methoxyaniline

: 1332333-40-0
N-[4-bromo-3-(methyloxy)phenyl]-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide

Guidance literature:: 4-bromo-3-methoxyaniline; With bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

2-[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetohydrazide; In dichloromethane; at -78 - 20 ℃;

Reference yield:

: 204688-61-9
2‐[(3S)‐1‐[(tert‐butoxy)carbonyl]pyrrolidin‐3‐yl]acetic acid

: 1332333-40-0
N-[4-bromo-3-(methyloxy)phenyl]-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / diethyl ether / 40 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.2: 0.08 h / 20 °C

2.3: 1 h / 0 - 20 °C

3.1: hydrazine hydrate / ethanol / 15 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / dichloromethane / -78 - 20 °C / Inert atmosphere

4.2: -78 - 20 °C

With hydrogenchloride; bis(trichloromethyl) carbonate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dmap; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane;

Reference yield:

: 1,1-dimethylethyl (3S)-3-[2-(ethyloxy)-2-oxoethyl]-1-pyrrolidinecarboxylate

: 1332333-40-0
N-[4-bromo-3-(methyloxy)phenyl]-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

1.2: 0.08 h / 20 °C

1.3: 1 h / 0 - 20 °C

2.1: hydrazine hydrate / ethanol / 15 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / dichloromethane / -78 - 20 °C / Inert atmosphere

3.2: -78 - 20 °C

With hydrogenchloride; bis(trichloromethyl) carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane;