6-[4-Fluoro-3-(4-methyl-2,5-dioxoimidazolidin-1-yl)benzyl]-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate

Base Information

Chemical Name:6-[4-Fluoro-3-(4-methyl-2,5-dioxoimidazolidin-1-yl)benzyl]-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate
CAS No.:959839-57-7
Molecular Formula:C₂HF₃O₂*C₁₇H₁₇FN₄O₃
Molecular Weight:458.369
Hs Code.:

Synonyms:6-[4-Fluoro-3-(4-methyl-2,5-dioxoimidazolidin-1-yl)benzyl]-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate

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Chemical Property of 6-[4-Fluoro-3-(4-methyl-2,5-dioxoimidazolidin-1-yl)benzyl]-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate

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Technology Process of 6-[4-Fluoro-3-(4-methyl-2,5-dioxoimidazolidin-1-yl)benzyl]-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate

There total 4 articles about 6-[4-Fluoro-3-(4-methyl-2,5-dioxoimidazolidin-1-yl)benzyl]-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-(3-{[N-(Ethoxycarbonyl)alanyl]amino}-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium Trifluoroacetate

: 959839-57-7
6-[4-Fluoro-3-(4-methyl-2,5-dioxoimidazolidin-1-yl)benzyl]-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 180 ℃; for 2h;

Reference yield:

: 959841-63-5
5-[(4,5-dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)methyl]-2-fluorobenzonitrile

: 959839-57-7
6-[4-Fluoro-3-(4-methyl-2,5-dioxoimidazolidin-1-yl)benzyl]-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / 1 h / 100 °C

1.2: 0 °C / pH 2 - 3

2.1: diphenyl phosphoryl azide; triethylamine / toluene / Heating / reflux

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C

5.1: water; acetonitrile

6.1: dmap / N,N-dimethyl-formamide / 2 h / 180 °C

With dmap; sodium hydroxide; diphenyl phosphoryl azide; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 2.1: Curtius Rearrangement;

Reference yield:

: 959841-64-6
5-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoic acid

: 959839-57-7
6-[4-Fluoro-3-(4-methyl-2,5-dioxoimidazolidin-1-yl)benzyl]-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / Heating / reflux

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C

4: water; acetonitrile

5: dmap / N,N-dimethyl-formamide / 2 h / 180 °C

With dmap; diphenyl phosphoryl azide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1: Curtius Rearrangement;