1-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol

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Chemical Name:1-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol
CAS No.:1032648-89-7
Molecular Formula:C₂₁H₁₂ClF₄N₅O
Molecular Weight:461.806
Hs Code.:

Synonyms:1-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol

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Chemical Property of 1-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol

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Technology Process of 1-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol

There total 1 articles about 1-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 917494-85-0
2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanone

: 1032650-41-1
4-chloro-7-bromo-5H-pyrrolo[3,2-d]pyrimidine

: 1032648-89-7
1-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol

Guidance literature:: 4-chloro-7-bromo-5H-pyrrolo[3,2-d]pyrimidine; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.0833333h;

2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanone; In tetrahydrofuran; pentane; at -78 ℃; for 0.25h;

With water; sodium hydrogencarbonate; ammonium chloride; trifluoroacetic acid; more than 3 stages;

Reference yield: 44.0%

: 1032648-89-7
1-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol

: 1032648-88-6
7-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: 1-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethanol; With water; trifluoroacetic acid; In 1,4-dioxane; at 70 ℃; for 18h;

With sodium hydrogencarbonate; In 1,4-dioxane; water;

With sodium hydrogencarbonate; trifluoroacetic acid; more than 3 stages;