methyl 3-(4-methoxy-3-[N-((4-(trifluoromethyl)phenyl)methyl)carbamoyl]phenyl)-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-(4-methoxy-3-[N-((4-(trifluoromethyl)phenyl)methyl)carbamoyl]phenyl)-2,2-dimethylpropanoate
CAS No.:311770-95-3
Molecular Formula:C₂₂H₂₄F₃NO₄
Molecular Weight:423.432
Hs Code.:

Synonyms:methyl 3-(4-methoxy-3-[N-((4-(trifluoromethyl)phenyl)methyl)carbamoyl]phenyl)-2,2-dimethylpropanoate

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Chemical Property of methyl 3-(4-methoxy-3-[N-((4-(trifluoromethyl)phenyl)methyl)carbamoyl]phenyl)-2,2-dimethylpropanoate

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Technology Process of methyl 3-(4-methoxy-3-[N-((4-(trifluoromethyl)phenyl)methyl)carbamoyl]phenyl)-2,2-dimethylpropanoate

There total 7 articles about methyl 3-(4-methoxy-3-[N-((4-(trifluoromethyl)phenyl)methyl)carbamoyl]phenyl)-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3300-51-4
p-Trifluoromethylbenzylamine

: 311770-92-0
methyl 3-(3-carboxy-4-methoxyphenyl)-2,2-dimethylpropanoate

: 311770-95-3
methyl 3-(4-methoxy-3-[N-((4-(trifluoromethyl)phenyl)methyl)carbamoyl]phenyl)-2,2-dimethylpropanoate

Guidance literature:: methyl 3-(3-carboxy-4-methoxyphenyl)-2,2-dimethylpropanoate; With chloroformic acid ethyl ester; triethylamine; In dichloromethane;

p-Trifluoromethylbenzylamine; In dichloromethane;
DOI:10.1021/jm0205144

Reference yield:

: 84923-70-6
5-formyl-2-methoxybenzoic acid

: 311770-95-3
methyl 3-(4-methoxy-3-[N-((4-(trifluoromethyl)phenyl)methyl)carbamoyl]phenyl)-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: KHCO₃ / dimethylformamide / 4 h / 20 °C

2.1: 99 percent / NaBH₄ / methanol / 2 h

3.1: 99 percent / pyridine; DMAP / CH₂Cl₂

4.1: 18 percent / Mg(ClO₄)2 / CH₂Cl₂ / 6 h / 20 °C

5.1: 90 percent / H₂ / Pd/C / tetrahydrofuran; ethanol / 5 h

6.1: Et₃N; ClCOOEt / CH₂Cl₂

6.2: 95 percent / CH₂Cl₂

With pyridine; dmap; sodium tetrahydroborate; magnesium(II) perchlorate; hydrogen; chloroformic acid ethyl ester; potassium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205144

Reference yield:

: 311770-87-3
benzyl 5-hydroxymethyl-2-methoxybenzoate

: 311770-95-3
methyl 3-(4-methoxy-3-[N-((4-(trifluoromethyl)phenyl)methyl)carbamoyl]phenyl)-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 99 percent / pyridine; DMAP / CH₂Cl₂

2.1: 18 percent / Mg(ClO₄)2 / CH₂Cl₂ / 6 h / 20 °C

3.1: 90 percent / H₂ / Pd/C / tetrahydrofuran; ethanol / 5 h

4.1: Et₃N; ClCOOEt / CH₂Cl₂

4.2: 95 percent / CH₂Cl₂

With pyridine; dmap; magnesium(II) perchlorate; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm0205144