(E)-4-hydroxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cimmamoylamide

Base Information

Chemical Name:(E)-4-hydroxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cimmamoylamide
CAS No.:868163-18-2
Molecular Formula:C₂₄H₃₁N₃O₃
Molecular Weight:409.528
Hs Code.:

Synonyms:(E)-4-hydroxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cimmamoylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-4-hydroxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cimmamoylamide

Chemical Property:

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Technology Process of (E)-4-hydroxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cimmamoylamide

There total 5 articles about (E)-4-hydroxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cimmamoylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 7400-08-0,50940-26-6
p-Coumaric Acid

: 21103-33-3
4-[4-(2-methoxyphenyl)piperazin-1-yl]butylamine

: 868163-18-2
(E)-4-hydroxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cimmamoylamide

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/j.bmc.2005.06.055

Reference yield: 47.0%

: 108608-03-3
4-hydroxycinnamic acid chloride

: 21103-33-3
4-[4-(2-methoxyphenyl)piperazin-1-yl]butylamine

: 868163-18-2
(E)-4-hydroxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cimmamoylamide

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/j.bmc.2005.06.055

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 868163-18-2
(E)-4-hydroxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-cimmamoylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃ / acetonitrile / 12 h / Heating

2.1: hydrazine hydrate / methanol / 2 h / Heating

2.2: 92 percent / HCl / methanol / 1 h / Heating

3.1: 76 percent / triethylamine; DCC / CH₂Cl₂

With potassium carbonate; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2005.06.055