benzyl N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

Base Information

• Chemical Name: benzyl N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate
• CAS No.: 96194-98-8
• Molecular Formula: C₁₈H₂₆N₂O₆
• Molecular Weight: 366.414
• Mol file: 96194-98-8.mol

Synonyms:benzyl N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

Chemical Property of benzyl N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

There total 8 articles about benzyl N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

α-benzhydryl O-benzyl-Nα-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate (96195-10-7) → benzyl Nα-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate (96194-98-8)

Guidance literature:

With sodium hydroxide; In acetone; for 1h; Ambient temperature;

DOI:10.1021/jo00213a013

Reference yield: 86.0%

benzyl 4-<3-(tert-butyloxycarbonyl)-5-oxo-4(S)-oxazolidinyl>butanohydroxamate (96195-11-8) → benzyl Nα-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate (96194-98-8)

Guidance literature:

With sodium hydroxide; In methanol; for 4h; Ambient temperature;

DOI:10.1021/jo00213a013

Reference yield:

N-benzyloxyamine (622-33-3) → benzyl Nα-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate (96194-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / tetrahydrofuran; H₂O / 1.) 0 deg C, 3 h, 2.) RT, overnight

2: 88 percent / 1 N NaOH / acetone / 1 h / Ambient temperature

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; acetone;

DOI:10.1021/jo00213a013

upstream raw materials:

benzyl 4-<3-(tert-butyloxycarbonyl)-5-oxo-4(S)-oxazolidinyl>butanohydroxamate

α-benzhydryl O-benzyl-N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

N-benzyloxyamine

di-tert-butyl dicarbonate

Downstream raw materials:

H-3-(Gly)2-OMe TFA

d(NHOBzl)-Gly-Gly-OMeBoc-

Boc-2-(Gly)2-OMe

d(NHOBzl)-Gly-Gly-OMeH-*TFA