Technology Process of 2-CHLORO-5-FLUORO-3-HYDROXYPYRIDINE
There total 1 articles about 2-CHLORO-5-FLUORO-3-HYDROXYPYRIDINE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hypochlorite; sodium hydroxide;
In
water;
at 20 ℃;
for 92h;
Cooling with liquid nitrogen;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C
1.2: 1 h / 10 - 35 °C
2.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 3 h / 100 °C
With
sodium hydride; sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C
1.2: 1 h / 10 - 35 °C
2.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 3 h / 100 °C
3.1: hydrogenchloride; water / tetrahydrofuran / 12 h / 10 - 35 °C
4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 27 h / 10 - 40 °C
With
hydrogenchloride; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;