(S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester

Base Information

• Chemical Name: (S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester
• CAS No.: 89121-14-2
• Molecular Formula: C₂₄H₄₀N₂O₆Si
• Molecular Weight: 480.677

Synonyms:(S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester

Chemical Property of (S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester

Chemical Property:

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Technology Process of (S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester

There total 1 articles about (S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(Trimethylsilyl)ethanol (2916-68-9) + Boc-Lys(Z)-OH (2389-45-9) → (S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester (89121-14-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; 1) ice-bath, 1 h, 2) refrigerator, 3 d;

DOI:10.1021/jo00181a043

Reference yield: 100.0%

(S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester (89121-14-2) + toluene-4-sulfonic acid (104-15-4) → Nε-(Benzyloxycarbonyl)-L-lysine 2-(Trimethylsilyl)ethyl Ester p-Toluenesulfonate (89106-04-7)

Guidance literature:

In benzene; for 1h; Heating;

DOI:10.1021/jo00181a043

Reference yield: 90.8%

(S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester (89121-14-2) → 6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester (89106-03-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

2-(Trimethylsilyl)ethanol

Boc-Lys(Z)-OH

Downstream raw materials:

Nε-(Benzyloxycarbonyl)-L-lysine 2-(Trimethylsilyl)ethyl Ester p-Toluenesulfonate

6-(4-benzoylbenzamido)-2-(tert-butoxycarbonylamino)hexanoic acid

(S)-6-(4-Benzoyl-benzoylamino)-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester

[(S)-5-(4-Benzoyl-benzoylamino)-1-((1S,2R)-1-carbamoyl-2-hydroxy-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

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