6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester

Base Information

Chemical Name:6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester
CAS No.:89106-03-6
Molecular Formula:C₁₉H₃₂N₂O₄Si
Molecular Weight:380.56
Hs Code.:

Synonyms:6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester

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Chemical Property of 6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester

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Technology Process of 6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester

There total 3 articles about 6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 2389-45-9
Boc-Lys(Z)-OH

: 89106-03-6
6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester

Guidance literature:: 2-(Trimethylsilyl)ethanol; Boc-Lys(Z)-OH; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 22h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h; Further stages.;
DOI:10.1021/ja005886l

Reference yield: 90.8%

: 89121-14-2
(S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester

: 89106-03-6
6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 89106-03-6
6-benzyloxycarbonylamino-2-L-amino-hexanoic acid trimethylsilyl ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / dichloromethane / 0.08 h / 0 °C

1.2: 24.25 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With dmap; trifluoroacetic acid; In dichloromethane;